UCAR-T for CD19+ Refractory/Relapsed B Hematologic Malignancies

Inclusion Criteria: Inclusion criteria applicable only to ALL: 1. Age ≥3 and \< 70 years old, gender is not limited; 2. Patients with a histologic diagnosis of CD19+ B-ALL according to the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines for Acute Lymphoblastic Leukemia (2016.v1); 3. Meet the R/R CD19+ B-ALL diagnosis, including any of the following conditions: A) No CR after standard chemotherapy; B) CR was induced for the first time, but the duration of CR was less than 12 months; C) R/R CD19+ B-ALL that failed after the first or repeated remedial therapy; D) 2 or more recurrences; 4. Number of primary cells (primary + juvenile) in bone marrow, \> 5% (morphology) and/or \> 1% (flow cytometry); 5. Philadelphia chromosomal negative (PH -) subjects;Philadelphia chromosomal positive (pH +) subjects who either cannot tolerate or do not respond to either of the TKI treatments; Inclusion criteria for NHL only: 1. Age ≥18 years old and \< 70 years old, regardless of gender; 2. According to the 2016 WHO classification criteria for lymphocytic tumors, the histological diagnosis included: DLBCL (NOS);Subjects with follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma transformation, and PMBCL and high-grade B-cell lymphoma; 3. Relapsed or refractory B-NHL (meets one of the following conditions) : A) Subjects have no remission or recurrence after receiving second-line chemotherapy regimen or above; B) primary drug resistance; C) Subjects relapse after autologous hematopoietic stem cell transplantation; 4. According to Lugano 2014 criteria, there should be at least one evaluable tumor focus; Common standards for ALL and NHL: 1. Serum total bilirubin ≤51 umol/L, serum ALT and AST ≤ 3 times of the upper limit of the normal range, serum creatinine ≤176.8 umol /L; 2. Echocardiography showed left ventricular ejection fraction (LVEF) ≥50%; 3. Subjects have no active pulmonary infection, and oxygen saturation of suction finger vein is ≥92%; 4. The estimated survival time is more than 3 months; 5. ECOG score 0-2; 6. Subjects or their legal guardians participate in this study voluntarily and sign the informed consent. Exclusion Criteria: 1. Extramedullary lesions, except those with effectively controlled CNSL (CNS-1);(All patients only) 2. A lymphoblastic crisis of chronic myeloid leukemia, Burkitt's leukemia/lymphoma, was diagnosed according to WHO classification;(All patients only) 3. having a genetic syndrome such as Fanconi anemia, Kostmann syndrome, Shwachman syndrome or any other known bone marrow failure syndrome;(All patients only) 4. Extranodal intracranial lesions (tumor cells in CSF and/or intracranial lymphoma shown on MRI);(For patients with NHL only) 5. subjects with extensive gastrointestinal lymphoma invasion;(For patients with NHL only) 6. Subjects received radiotherapy, chemotherapy and monoclonal antibody treatment within 1 week before screening; 7. Have a history of allergy to any one ingredient in cell products; 8. Prior use of any CAR T cell product or other genetically modified T cell therapy 9. Subjects with cardiac dysfunction grade III or IV according to the New York Heart Association (NYHA) cardiac function classification standards; 10. Myocardial infarction, cardiac angioplasty or stenting, unstable angina pectoris or other clinically serious heart disease within 12 months of enrollment; 11. Severe primary or secondary hypertension of grade 3 or higher (WHO Hypertension Guidelines, 1999); 12. Patients with prolonged QT interval indicated by ECG and previous severe heart disease such as severe arrhythmia; 13. Previous history of craniocerebral trauma, disturbance of consciousness, epilepsy, cerebrovascular ischemia, cerebrovascular hemorrhagic disease, etc. 14. Severe active infection (except simple urinary tract infection and bacterial pharyngitis); 15. Subject has a history of other primary cancers except for: A. Non-melanoma cured by excision, such as basal cell carcinoma of the skin; B. Cervical carcinoma in situ, local prostate cancer, and ductal carcinoma in situ with disease-free survival ≥2 years after adequate treatment; 16. Subjects with autoimmune diseases requiring treatment or subjects requiring immunosuppressive therapy; 17. Patients with graft-versus-host disease (GVHD) and/or requiring immunosuppressive therapy; 18. Live vaccine inoculation within 4 weeks before screening; 19. Subjects have a history of alcohol, drug abuse or mental illness; 20. During screening, if the subjects were HBV surface antigen positive, they were tested by active hepatitis B PCR. If HBV DNA copy number \> 1000, they were excluded; if HBV DNA copy number ≤1000, routine antiviral treatment was required after enlistment).Hepatitis C, syphilis antibody positive, syphilis virus DNA test exceeded the upper limit of normal value and CMV virus DNA test exceeded the upper limit of normal value; 21. Subjects who were receiving systemic steroid therapy prior to screening and were determined by the investigator to require long-term systemic steroid therapy during the treatment period (other than inhalation or topical use); 22. Screening participants who had participated in other clinical trials within the previous 2 weeks; 23. Pregnant and lactating women and fertile subjects who are unable to take effective contraceptive measures (both male and female); 24. Any situation that the investigator believes may increase the risk to the subject or interfere with the outcome of the study.