Effect of Ultrasound-guided Transversus Abdominis Plane Block After Laparoscopic Bariatric Surgery

Tianjin Medical University General Hospital120 enrolled

Overview

Purpose: To explore and compare Ultrasound-Guided Transversus Abdominis Plane Block on Postoperative nausea and vomiting and Early Outcome After Laparoscopic Bariatric Surgery To evaluate and examine TAPB can reduce the application of intraoperative and postoperative opioids and the duration of analgesia

Poor postoperative nausea and vomiting control is a leading factor that hinders the physical rehabilitation, and causes acute cognitive impairment and chronic pain syndrome. Recently, the multimodal analgesia strategies to minimise opioid-related side effects are highly desirable in open surgical procedures. The transversus abdominis plane block is a novel technique involving injection of local anaesthetic between the internal oblique and the transversus abdominis muscles of the abdominal wall. Although ropivacaine is most commonly used for this technique, the analgesic duration remains not dissatisfied. Herein, we will evaluate the efficacy of ultrasound-guided transversus abdominis plane (USG-TAP) block with ropivacaine in Laparoscopic Bariatric Surgery

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

120

Conditions

Nausea and Vomiting Laparoscopic Bariatric Surgery

Interventions

RopivacaineDRUG

Before the induction of anesthesia, ropivacaine is used for bilateral transversus abdominis plane block in a volume of 20 mL of each side

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Subject is scheduled to undergo Laparoscopic Bariatric Surgery 2. Subject's American Society of Anesthesiologists physical status is I-III. 3. BMI\>35kg/m2 4. The subject's parent/legally authorized guardian has given written informed consent to participate Exclusion Criteria: 1. Subject has a diagnosis of renal or liver failure. 2. Subject has a diagnosis of mental illness 3. Subject is allergy and contraindication to Ropivacaine. 4. Subject has a history of chronic pain, a history of alcohol or opioid abuse, pre-existing therapy with opioids, intake of any analgesic drug within 48 hours before surgery. 5. Subject has any contraindication for the use of patient-controlled analgesia (PCA). 6. Subject is pregnant or breast-feeding.

Locations (2)

Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, China

RECRUITING

Zhen Jia

Tianjin, Tianjin Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Postoperative nausea and vomiting

Time frame: 72 hours after surgery

Secondary Outcomes

Cumulative Sufentanyl Consumption

Each patient was administered analgesics using a PCA pump containing sufentanil (100μg) in normal saline at a total volume of 100 ml after leaving PACU. This device was set to deliver a basal infusion of 2 ml/h and bolus doses of 0.5 ml with a 15-min lockout period. Sufentanyl cumulative consumption is recorded 24 hours postoperatively

Time frame: 24 hours after surgery

Time of First Postoperative Analgesic Requirement

First postoperative pain (NRS≥4) is initially controlled by titration of sufentanyl

Time frame: 1 hour after surgery

Occurrence of Side Effects

Occurrence of side effects: nausea, vomiting, dizziness, headache, shivering, pruritus

Time frame: 24 hours after surgery

Total Dose of First Postoperative Analgesic Requirement

First postoperative pain (NRS≥4) is initially controlled by titration of sufentanyl.

Time frame: 1 hour after surgery

Central Contacts

Zhen Jia, MD

CONTACT

13002211205 1464322162@qq.com

Data from ClinicalTrials.gov

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