GOLD 0 - DLCO 1: A Look Beyond the Obstruction. Is Spirometry Enough for COPD (Chronic Obstructive Pulmonary Disease) Screening?

Risk factors associated to the development of COPD

Risk factors associated to the development of COPD

Time frame: through study completion, an average of 5 years

Changes from baseline of inflammatory Markers at 2 and 5 years

To Study soluble receptors involved in inflammation processes and tissue repair in early disease stages.

Time frame: 2 and 5 years

Oxidative stress

To Study of oxidative stress parameters in early disease stages

Time frame: through study completion, an average of 5 years

Diffusion study

To Characterize patients in stage 0 of GOLD with impaired diffusion

Time frame: through study completion, an average of 5 years

Changes from baseline of High Resolution Computed Tomography (HRTC) at 5 years

To determine changes in HRCT to identify subgroups of patients with different clinical and evolutionary trajectories

Time frame: Baseline and 5 years

Airflow limitation Study

To Investigate the contribution of measuring lung volumes for the diagnosis of COPD when there is no evidence of airflow limitation in spirometry (GOLD 0).

Time frame: through study completion, an average of 5 years

Gender differences in value of diffusion (DLCO)

To assess if there are differences between men and women with diffusion disorder

Time frame: through study completion, an average of 5 years

Childhood background

To assess whether factors, such as the effect of lung development during childhood and adolescence, bronchial hyperreactivity and / or the role of infections influences the risk of developing the disease or its progression.

Time frame: Baseline

Comorbidity

To characterize the comorbidities associated with GOLD 0 patients and altered diffusion.

Time frame: through study completion, an average of 5 years