RADIANCE Continued Access Protocol

Inclusion Criteria: * Average office BP ≥140/90 mmHg at screening visit despite taking stables doses of antihypertensive medications for at least 4 weeks prior to consent * Documented daytime ABP ≥135/85 mmHg following 4 week run-in/standardization period on antihypertensive medication regimen Exclusion Criteria: * Renal artery anatomy ineligible for treatment * Secondary hypertension not including sleep apnea * Type I diabetes mellitus or uncontrolled Type II diabetes (defined as plasma HbA1c ≥9.0%) * eGFR \<40 * Brachial circumference ≥42 cm * Any history of cerebrovascular event or severe cardiovascular event within 3 months prior to consent * Documented repeat (\>1) hospitalization for hypertensive crisis within 3 months prior to consent * Documented confirmed episode(s) of unstable angina within 3 months prior to consent * Chronic oxygen support or mechanical ventilation other than nocturnal respiratory support for sleep apnea * Primary pulmonary hypertension * Night shift workers * Pregnant, nursing or planning to become pregnant