Objective to investigate the protective effect of preoperative electroacupuncture on lung function in patients with mechanical ventilation for more than 2 hours under general anesthesia
Randomized parallel control study. From September 1, 2021 to December 31, 2022, patients with mechanical ventilation time more than 2 hours will be randomly divided into electroacupuncture pretreatment group and blank control group. The blood gas index, ventilator parameters and serum inflammatory factor concentration of patients will be evaluated to evaluate whether electroacupuncture has protective effect on lung function of patients with mechanical ventilation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
72
In the electroacupuncture group, acupoints of Lieque (+), Chize (-), Sanyinjiao (-), Zusanli (+), Tanzhong (+) and Yutang (-) will be selected for electrical stimulation. Density wave will be selected, and the current intensity should be tolerated by the patients. Conventional anesthesia operation could be started after the connection of electroacupuncture, and acupuncture point stimulation will be stopped 30min later.
oxygenation index
record oxygenation index
Time frame: Before anesthesia
oxygenation index
record oxygenation index
Time frame: 2 hours after tracheal intubation
oxygenation index
record oxygenation index
Time frame: 5 minutes after tracheal intubation removal
Postoperative comfort score
Assess the quality of recovery during recovery
Time frame: during anesthesia recovery period
sedation score (Ramsay)
Assess the quality of recovery during recovery
Time frame: during anesthesia recovery period
restfulness score (DRS)
Assess the quality of recovery during recovery
Time frame: during anesthesia recovery period
visual analogue scale (VAS)
Assess the quality of recovery during recovery
Time frame: during anesthesia recovery period
Length of stay
Assess the quality of postoperative recovery
Time frame: 1 week after discharge, the patient's length of stay will be recorded through medical record system
postoperative time in hospital
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Assess the quality of postoperative recovery
Time frame: 1 week after discharge, the patient's postoperative time in hospital will be recorded through medical record system
postoperative complications of major organs
Assess the quality of postoperative recovery
Time frame: Major organ complications during hospitalization，assessed up to 30 days after surgery
mortality within 30 days
Assess the quality of postoperative recovery
Time frame: mortality within 30 days will be recorded
Expression of IL-18 in serum
The perioperative inflammation level will be assessed
Time frame: Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-18 in serum will be detected by flow cytometry
Expression of IL-18 in serum
The perioperative inflammation level will be assessed
Time frame: 5minutes after tracheal intubation removal the radial artery blood samples will be collected, and the expressions of IL-18 in serum will be detected by flow cytometry
Expression of IL-1β in serum
The perioperative inflammation level will be assessed
Time frame: Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-1β in serum will be detected by flow cytometry
Expression of IL-1β in serum
The perioperative inflammation level will be assessed
Time frame: 5minutes after tracheal intubation removal the radial artery blood samples will be collected, and the expressions of IL-1β in serum will be detected by flow cytometry
Expression of IL-10 in serum
The perioperative inflammation level will be assessed
Time frame: Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-10 in serum will be detected by flow cytometry
Expression of IL-10 in serum
The perioperative inflammation level will be assessed
Time frame: 5minutes after tracheal intubation removal the radial artery blood samples will be collected, and the expressions of IL-10 in serum will be detected by flow cytometry
Mean arterial pressure
Intraoperative vital signs will be recorded
Time frame: Before anesthesia ,2 hours after tracheal intubation , and 5minutes after tracheal intubation removal
heart rate
Intraoperative vital signs will be recorded
Time frame: Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal
BIS
Intraoperative vital signs will be recorded
Time frame: Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal
extubation time
Intraoperative vital signs will be recorded
Time frame: Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal
anesthesia dosage
Intraoperative vital signs will be recorded
Time frame: Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal