The main goal of the study was to characterize the morbidity, immunological, microbiolical and clinical phenotypes of patients with treated- resistance to Helicobacter pylori (HP) infection, and the effect of triple therapy including the levofloxacin. Control groups were newly diagnosed, previously infected and never infected HP patients
See Nestegard O, et al. PLOS ONE \| https://doi.org/10.1371/journal.pone.0238944 September 23, 2020
Study Type
OBSERVATIONAL
Enrollment
185
Triple therapy of Helicobacter pylori including two antibiotics and a proton inhibitor for 10 days
Characterization of patients with chronic HP infection resistant to previous conventional triple therapy
Clinical data including endoscopy, histology, microbiological data including resistance measurements, immunological data (mucosal tranacrips), effect of triple therapy
Time frame: 2010-2012
Endoscopy
endoscopic description of mucosa bye endoscopy
Time frame: 2010-2012
Histology
Histological characterizations of inflammation (Sydney) of gastric mucosa
Time frame: 2010-2012
Immunology
Immunological mucosal characterizations of pro- and antiinflammatory cytokine transcript (PCR)
Time frame: 2010-2012
HP microbiology
HP microbiology sensitivity to metronidazol, amoxicillin, clarithromycine, levofloxacin and tetracycline
Time frame: 2010-2012
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