In the present study the investigators compare the clinical outcome corneal cross linking with either the stand-ard Dresden (sCXL) or the accelerated custom-fast (aCFXL) ultraviolet A irradiation protocol using riboflavin-D-α-Tocopheryl polyethyleneglycol1000 succinate for progressive keratoconus.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
41
The accelerated custom fast CXL (aCFXL) has been developed on a published mathematical model that takes into consideration objective variables such as the equation governing the UVA-induced riboflavin consumption rate and the corneal thickness at its thinnest point. By knowing both values, the mathematical model allows to objectively calculate both the exact UVA irradiation value (intensity), expressed in mW/cm2, and the irradiation time
The standard CXL procedure has been carried on following the Dresden protocol
Pellegrini Hospital
Naples, Italy
Topographical parameters
Maximum keratometry: diopters Mean keratometry: diopters Minimum corneal tickness: diopters
Time frame: 2 years
Refractive parameters
Corrected distance acuity (BCVA): Logarithm of the Minimum Angle of Resolution (logMAR)
Time frame: 2 years
Refractive parameters
Spherical equi-valent: diopters Refractive cylinder magnitude: diopters
Time frame: 2 years
Biomechanical parameters
Corneal hysteresis: mmHg
Time frame: 2 years
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