Effect of Proximal Blood Flow Arrest During Endovascular Thrombectomy

Inclusion Criteria: * Age ≥18 years * Acute ischemic stroke presenting with a neurological deficit of (NIHSS ≥2) * Intracranial arterial occlusion of the distal internal carotid artery or middle cerebral artery (M1/M2 segments) demonstrated with on clinical neuroimaging such as: computed tomography angiogram (CTA), magnetic resonance imaging angiogram (MRA), or digital subtraction angiography (DSA). * ASPECTS score of \>4 or by locally accepted ischaemic core/penumbra mismatch using computed tomography perfusion or magnetic resonance (CTP or MR) imaging. * modified Rankin Scale, mRS\<3 * Intention to treat with aspiration only or combination technique of stent-retriever + aspiration in the first pass attempt during endovascular thrombectomy Exclusion Criteria: * Severe stenosis (\>90%), or tandem occlusion of the ipsilateral extracranial internal carotid artery. * Previously deployed stents in the ipsilateral internal carotid artery. * Dissections of the ipsilateral internal carotid artery. * Unlikely to be available for 90 days follow-up (e.g. no fixed home address, visitor from overseas). * Subject participating in a study involving an investigational drug or device that would impact this study.