This study will be done to investigate the effectiveness of a 24-week multidomain intervention program consisting of cognitive training, exercise, nutrition management, vascular disease risk factor management, social activity, and motivational enhancement on the cognitive function compared to the control group in mild cognitive impairment.
The physical exercise program will consist of aerobic exercise, exercise to enhance balance and flexibility, muscle-strengthening activities involving major muscle groups, and finger-toe movements. Cognitive training targets the cognitive domains of episodic memory, executive function, attention, working memory, calculation, and visuospatial function. Cognitive training will be conducted using a tablet-based application. Participants will be advised to eat something according to the recommendation of the MIND diet. They will also meet the study nurse every 4 weeks for anthropometric measurements and monitoring of smoking and alcohol intake. The purpose of the motivational enhancement program is to induce, maintain, and strengthen motivation, which is a psychological resource to help maintain dementia prevention activities.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
300
For 24 weeks, participants will receive cognitive training using the tablet PC application twice a week, exercise 3 times a week, nutrition education 12 times, anthropometric measurements and alcohol and smoking monitoring every 4 weeks, motivation reinforcement training 4 times.
Dong-A University Hospital
Busan, South Korea
Pusan National University Hospital
Busan, South Korea
Eulji University Hospital
Change of cognition
Repeatable Battery for the Assessment of Neuropsychological Status (range 40-160). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of global cognition
Mini-Mental State Examination (range 0-30). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of function
Clinical Dementia Rating scale-Sum of Boxes (range 0-18). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Change of subjective memory
Prospective and Retrospective Memory Questionnaire (range 16-80). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Change of depression
Geriatric Depression Scale-15 items (range 0-15). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Change of quality of life
Quality of life-Alzheimer's disease (range 0-52). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of activities of daily living
Bayer Activities of Daily Living (range 1-10). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Change of nutritional behavior
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Daejeon, South Korea
Myungji Hospital
Goyang-si, South Korea
Chonnam University Hospital
Gwangju, South Korea
Inha University Hospital
Incheon, South Korea
Catholic Kwandong University International St. Mary's Hospital
Incheon, South Korea
Jeonbuk National University Hospital
Jeonju, South Korea
Bobath Memorial Hospital
Seongnam, South Korea
CHA Bundang Medical Center
Seongnam, South Korea
...and 7 more locations
Nutrition Quotient for elderly (range 0-100). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of nutrition
Mini Nutritional Assessment (range 0-14). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of motor function
Short Physical Performance Battery (range 0-12). Higher scores indicate better performance.
Time frame: Change from Baseline at 24 weeks
Change of sleep quality
Pittsburgh Sleep Quality Index (range 0-21). Higher scores indicate worse performance.
Time frame: Change from Baseline at 24 weeks
Change of motivation
Self Determination Index (SDI). Higher scores of SDI indicate better performance.
Time frame: Change from Baseline at 24 weeks. Higher scores indicate better performance.