NCT05024110 - Effect of Exercise Intensity on Vitamin D | Crick

Overview

Children with Down's syndrome (DS) are more liable to vitamin D deficiency. Treating this deficiency with supplements is associated with the risk of intoxication due to increased intestinal absorption or decreased vitamin D metabolism. The aim of the study was to compare the effect of two exercise intensities on the modulation of vitamin D and Parathormone (PTH) levels in children with DS.

Forty-four DS male children aged from 8-12 years participated in the study. The subjects were assigned randomly into two equal groups. group I received high-intensity treadmill aerobic exercises (T-AE) and group II received moderate-intensity T-AE, three times per week for three months. the blood samples were collected from both groups before the intervention, after one month of intervention, then after three months of intervention to assess serum 25(OH)D and PTH levels.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

44

Conditions

Down Syndrome Vitamin D Deficiency

Interventions

High intensity treamill exercise training.OTHER

We used the Martti Karvonen formula to calculate the heart rate zone. Firstly, the resting heart rate (rest-HR) was detected for every participant by inviting him to lie in a prone position for 10 minutes while catching a heart rate monitor. After that, the maximum heart rate (max-HR) was calculated by utilizing this formula: maximum heart rate =220- age. Then, we calculated the heart rate reserve (HRR) by using the law: HRR= max-HR - resting HR. Exercise intensity is represented as a percentage of HRR. Finally, the target heart rate (target-HR) was calculated by using the formula: target-HR = HRR x intensity% + rest-HR. Moderate-intensity exercises are defined as the activity which uses 50% to 70% of the HRR, while high-intensity exercises use 70% to 90% of the HRR

Moderate intensity treamill exercise training.OTHER

We used the Martti Karvonen formula to calculate the heart rate zone. Firstly, the resting heart rate (rest-HR) was detected for every participant by inviting him to lie in a prone position for 10 minutes while catching a heart rate monitor. After that, the maximum heart rate (max-HR) was calculated by utilizing this formula: maximum heart rate =220- age. Then, we calculated the heart rate reserve (HRR) by using the law: HRR= max-HR - resting HR. Exercise intensity is represented as a percentage of HRR. Finally, the target heart rate (target-HR) was calculated by using the formula: target-HR = HRR x intensity% + rest-HR. Moderate-intensity exercises are defined as the activity which uses 50% to 70% of the HRR, while high-intensity exercises use 70% to 90% of the HRR

Eligibility

Sex: MALEMin age: 8 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * all subjects were trainable and able to walk freely without assistance. * Had vitamin D deficiency, the serum level of 25-hydroxyvitamin D (25(OH) D) was ranged from 10-20ng/mL. * Did not take calcium or vitamin D3 supplements, medications for osteoporosis, antiepileptic drugs, or any medications that may affect the vitamin D metabolism in the last 5 months. * The feeding method during the first two years of age for all children was bottle feeding. * Mild to moderate mentally retarded, (IQ ranged from 45-70) to be able to understand and obey simple orders. * free from any medical consequences for example cardiopulmonary disorders, auditory defects, and visual impairments. * Had no previous history of strength training. * Body mass index percentile ranged from the 50th percentile to less than the 75th percentile (healthy). * The feeding method was by mouth with no special diet, with an absence of signs of malnutrition Exclusion Criteria: * autoimmune disease. * Renal diseases. * Have taken any thyroid medications. * Obesity. * epileptic fits.

Locations (1)

College of applied medical sciences

Ta'if, Mecca Region, Saudi Arabia

Outcomes

Primary Outcomes

vitamin d after one month

serum level of 25(OH) D ng/ml after one month of intervention

Time frame: one month

vitamin d after three months

serum level of 25(OH) D ng/ml after three months of intervention

Time frame: three months

PTH after one month

Serum level of parathormone (PTH) pmol/L after one month of intervention

Time frame: one month

PTH after three months

Serum level of parathormone (PTH) pmol/L after three months of intervention

Time frame: three months