Renal Denervation and pUlmonary Vein isolAtion With cryoabLation on Patients With Atrial Fibrillation and hypErtension

Inclusion Criteria: 1. Age ≥18 years old, and \<75 years old, gender is not limited; 2. Hypertensive patients with symptomatic paroxysmal atrial fibrillation to be treated by catheter ablation with substandard blood pressure. SBP ≥ 150 mmHg or DBP ≥ 90 mmHg in patients taking at least one antihypertensive drug; 3. Agree to participate and sign the informed consent. Exclusion Criteria: 1. Cannot accept catheter ablation (such as thrombus in left atrium/left atrial appendage, recent myocardial infarction, stroke, etc.); 2. Patients with obvious bleeding tendency or unable to accept postoperative anticoagulation; 3. The anteroposterior diameter of left atrium indicated by echocardiography was ≥50mm; 4. A history of left atrial surgery or left atrial interventional therapy (including cryo-ablation, radiofrequency ablation, left atrial appendage occlusion, etc.); 5. NYHA grade IV congestive heart failure or LVEF \<30%; 6. patients with valvular atrial fibrillation and secondary atrial fibrillation (such as uncontrolled hyperthyroidism, acute alcoholism, atrial fibrillation after cardiac surgery, etc.); 7. Patients with typical atrial fluttering or other supraventricular tachycardia (duration greater than 30s) confirmed by preoperative electrocardiogram or dynamic electrocardiogram; 8. Severe organic heart disease, including moderate to severe mitral insufficiency or stenosis, previous myocardial infarction, hypertrophic cardiomyopathy, etc.; 9. Patients with secondary hypertension; 10. Uncontrollable pulmonary hypertension; 11. Patients with glomerular filtration rate (EGFR) \< 45ml/min/1.73m2 or patients with chronic kidney disease, nephrotic syndrome, polycystic kidney disease and other renal diseases were estimated according to MDRD calculation method; 12. Renal artery imaging (renal artery CTA) exclusion criteria: 1. inability to access the renal vascular system; 2. Diameter of renal aorta less than 4 mm or length less than 20 mm; 3. Hemodynamic or anatomical renal artery abnormalities or stenosis; 4. A history of previous renal artery interventions, including balloon angioplasty or stenting; 5. There are multiple unilateral renal aortas leading to the kidney; 13. Participated in other clinical studies and not yet enrolled in the group; 14. Women who are pregnant, lactating or preparing to become pregnant; 15. Life expectancy less than 1 year; 16. Other conditions that are not suitable for inclusion in this study as assessed by the researcher, such as mental disorders or psychological disorders; 17. A history of acute coronary events or percutaneous coronary stent intervention, a history of stroke or transient ischemic attack, and extensive atherosclerosis with intravascular thrombosis within the last 6 months; 18. Patients with ICD implantation history or CRT treatment history.