This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research. Thus a large part of this pilot study will be to demonstrate feasibility and reliability, and use this experience to develop a feasible protocol for ongoing research. The specific short-term objectives are: 1. To establish the feasibility of performing large-scale deep cognitive phenotyping using online cognitive testing. 2. To demonstrate that online neurocognitive testing is valid and reliable in a smaller sample of locally recruited participants tested both in-lab and online.
Study Type
OBSERVATIONAL
Enrollment
1,000
We are assessing several cognitive domains and have made minor adaptations (reducing the total number of trials or lengthening response windows) to several standard neuropsychology tests including measures of executive function, working memory, visuospatial function, declarative memory, reward processing, response inhibition. Overall, the tests we use follow a standard set-up: participants are shown stimuli on the screen and are asked to provide a response using either a keyboard or a mouse, based on a specific set of instructions. We always provide a detailed set of on-screen instructions and a practice phase. In some cases, information about performance is provided in the form of points, in other cases, none is provided.
McGill University Health Centre
Montreal, Quebec, Canada
RECRUITINGCompletion rate of cognitive test set (feasibility)
Proportion of registered participants who complete all the cognitive testing.
Time frame: Measured once, as this is a cross-sectional study (time to complete cognitive tests is estimated to be 1.5 hours)
Reliability of web-based vs in-person working memory testing (n-back test)
Intraclass correlation coefficient for web-based vs. in-person performance on the n-back test will be computed
Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart
Reliability of web-based vs in-person executive function testing (Stroop test performance)
Intraclass correlation coefficient for web-based vs. in-person performance on the Stroop test will be computed
Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart
Reliability of web-based vs in-person visuospatial function testing (Trail making test performance)
Intraclass correlation coefficient for web-based vs. in-person performance on the Trail making test will be computed
Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart
Reliability of web-based vs in-person declarative memory testing (recognition memory)
Intraclass correlation coefficient for web-based vs. in-person performance on the image recognition test will be computed
Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart
Reliability of web-based vs in-person reward processing testing
Intraclass correlation coefficient for web-based vs. in-person performance on the probabilistic reward task will be computed
Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart
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