Remimazolam and Remifentanil Without Neuromuscular Blocking Agent

Seoul National University Bundang Hospital38 enrolled

Overview

Remimazolam is a novel drug approved for induction and maintenance of general anesthesia. This study aims to check the appropriate dose and patient response by administering remimazolam and remifentanil in surgery that does not require a neuromuscular blocking agents.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Myoma;Uterus Polyp Endometrium Unspecified Condition Associated With Female Genital Organs and Menstrual Cycle

Interventions

RemimazolamDRUG

Loading for anesthesia induction: Remimazolam 6 mg/kg/h until loss of consciousness Continuous infusion for anesthesia maintenance: Remimazolam 1-2 mg/kg/h under the Bispectral index monitoring

Eligibility

Sex: FEMALEMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult woman scheduled for gynecological surgery under general anesthesia * American Society of Anesthesiology grade 1 or 2 * When using a laryngeal mask airway to maintain general anesthesia Exclusion Criteria: * Underlying diseases: liver, kidney, brain nervous system, glaucoma * Patients with BMI greater than 30 and less than 18.5 * Patients diagnosed with sleep apnea * Alcohol or drug dependent patients * Patients with severe or acute respiratory failure * Lactose intolerance * Dextran 40 hypersensitivity * Patients in shock or coma

Locations (1)

Seoul National University Bundang Hospital

Seongnam, South Korea

Outcomes

Primary Outcomes

Remimazolam induction dose

Time frame: During the anesthesia induction (from initiation of anesthesia until the insertion of laryngeal mask airway)

Remimazolam maintenance dose

Time frame: During the anesthesia maintenance (from the insertion of laryngeal mask airway until stopping remimazolam infusion)

Secondary Outcomes

Use of rescue midazolam

Time frame: During the anesthesia (from initiation of anesthesia until stopping remimazolam infusion)

Use of rescue rocuronium

Time frame: During the anesthesia (from initiation of anesthesia until stopping remimazolam infusion)

Use of flumazenil

Time frame: During the anesthesia recovery (from stopping remimazolam infusion until the recovery of consciousness)

Data from ClinicalTrials.gov

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