The Medical Management in Patients Exposed to Weapons of Mass Destruction

N/AEnrolling By InvitationNCT05026645

St. Justine's Hospital1,000 enrolled

Overview

Observation study measuring medical response in contaminated environment.

This is an ongoing multicentric observational study that aims to assess the medical response to chemical, biological, radiological, nuclear, explosive (cbrne) events during the last five (5) decades (i.e.: 1970-2020), and in any future cbrne attack that might occur within the next 15 years (i.e.: 2021-2036). Of note, the data collection will be performed retrospectively and after sites review ethic board (REB) approval.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Chemical Injury Chemicals; Intoxication Acute Respiratory Distress Syndrome Distress Respiratory Syndrome Medical Emergencies

Interventions

Clinical interventions performed in acute settings (contaminated environment)PROCEDURE

Any clinical intervention performed on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic).

Protection (clinician and patient)PROCEDURE

As interrelated competence of the clinical intervention, any protection procedure and capability applied on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic). Concerning the clinician, the protection implied for his/her own safety and for the patient to whom she/he was in closed/contact with.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: i. a CBRNE attack caused at least one casualty who required the assistance of the participating health care system (e.g.: physicians, nurses, paramedics and other health-care specialists of a medical facility) during a medical extraction from the incident site until admission to a medical facility; ii. Patients are eligible if they were exposed to the CBRNE attack; iii. Medical information concerning the CBRNE exposures, even if partial, is accessible to health care professionals for the purposes of filling out the online case report form (eCRF); iv. Participants must be able to complete the online case report form in English; and v. The approval of an Ethics Review Board is obtained by each medical centre participant. Exclusion Criteria: A negative response to any of the inclusion criteria results in an exclusion.

Locations (15)

Director, Unconventional Weapons & Technology Division, National Consortium for the Study of Terrorism and Responses to Terrorism University of Maryland

College Park, Maryland, United States

Centre for Defence and Security Studies, University of Manitoba

Outcomes

Primary Outcomes

Intervention and location

The percentage of patients to whom the World Health Organization's healthcare guidelines were applied without any delay (i.e.: during a medical extraction/evacuation)

Time frame: At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).

Secondary Outcomes

Contamination is under-control due to efficient protective measures applied during a medical extraction/evacuation

The percentage of patients whose health condition remained stable during a medical extraction due to efficient WHO's protective measures applied

Time frame: At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).

Contamination under-control due to efficient decontamination measures applied during a medical extraction/evacuation

The percentage of patients whose health condition remained stable during a medical extraction due to efficient WHO's decontamination measures applied

Time frame: At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).

Deterioration of the patient's health condition due to compromised means of protection

The percentage of patients whose health condition deteriorate during a medical extraction due to the misuse of WHO's protective measures (e.g.: mask, suit, gloves, boots, etc).

Time frame: At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).

Deterioration of the patient's health condition due to compromised means of decontamination

The percentage of patients whose health condition deteriorated during a medical extraction due to the misuse of WHO's decontamination measures (e.g.: immediate (roughly) or/and thorough (specialized one)).

Data from ClinicalTrials.gov

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