Experiencing the death of a loved one is inevitable for older adults. Before the coronavirus disease 2019 (COVID-19) pandemic, over 2.5 million people died annually in the United States, including 52,000 in Wisconsin alone, and COVID-19 has added to this toll. Each person who dies leaves an average of five grieving people behind. Most grieving older adults are resilient and recover their pre-loss functioning within one year. However, in about 10%, acute grief becomes protracted and debilitating, leading to the development of prolonged grief disorder (PGD), a clinically diagnosable mental health condition. PGD in older adults increases the risk for poorer medical, mental health, and cognitive outcomes; lower quality of life; disability; premature mortality; and suicide. Despite the magnitude of this problem, the neurobiology of PGD in older adults is poorly understood. By using Iyengar Yoga (IY) as a probe for PGD neurobiology, this pilot project aims to address this critical gap.
Our goal is to conduct a pilot study to examine in PGD the modulating effects of 10-week IY on circulating endocannabinoid and emotion processing brain circuit, and the associations between biological changes and clinical response.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
68
Participation in Iyengar Yoga classes
Participation in socialization control group sessions
Medical College of Wisconsin
Wauwatosa, Wisconsin, United States
Change in circulating endocannabinoid concentrations
Change in circulating endocannabinoids from baseline to post-intervention
Time frame: 10 weeks
Change in neural activity measured using Functional magnetic resonance imaging (fMRI)
Change in neural activity from baseline to post-intervention
Time frame: 10 weeks
Inventory of Complicated Grief (ICG) scale score change
ICG score ranges from 0 to 76 (higher scores indicate worse outcome)
Time frame: 10 weeks
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