Effect of Desflurane Versus Sevoflurane With Recent Bio-markers on Renal and Hepatic Functions

Theodor Bilharz Research Institute70 enrolled

Overview

Studying the effects of both inhalational anesthetics desflurane and sevoflurane on hepatic integrity and renal function, guided by recent blood and urine biomarkers in patients undergoing laparoscopic cholecystectomy surgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Postoperative Complications

Interventions

Neutrophil Gelatinase-Associated Lipocalin (NGAL)DIAGNOSTIC_TEST

The evaluation of inhalational anesthetics (desflurane and sevoflurane) on NGAL levels in laparoscopic cholecystectomy patients.

DesfluraneDRUG

Desflurane

SevofluraneDRUG

Sevoflurane

Eligibility

Sex: ALLMin age: 25 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. American Society of Anesthesiologists (ASA) Class: I\&II. 2. Elective laparoscopic cholecystectomy. 3. Age: 25-55 years. 4. Gender: Both male and female. 5. Body Mass Index (BMI): 18.5-24.9 km2-(Normal weight). Exclusion Criteria: 1. Extremes of age. 2. Abnormal hepatic function by alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values outside the normal range. 3. Abnormal renal function by blood urea nitrogen (BUN) and creatinine above the normal ranges. 4. Hypertension, unstable angina pectoris or myocardial infarction within the last six months. 5. Pregnancy and lactation. 6. Bronchial asthma. 7. Drug allergies. 8. Alcohol or drug addiction. 9. General anesthesia within the last three months.

Locations (1)

Theodor Bilharz Research Institute

Cairo, Egypt

Outcomes

Primary Outcomes

Change in serum Neutrophil gelatinase-associated lipocalin (NGAL)

Renal Biomarker

Time frame: a change from baseline NGAL serum level at 6 hours