The Influence of Meibomian Gland Expression on Corneal Aberrations in MGD Patients

Wenzhou Medical University62 enrolled

Overview

To evaluate the influence of corneal-aberrations before and after the meibomian gland thermal massage treatment.

62 MGD patients treated with meibomian gland thermal massage once a week for 3 to 4 weeks were recruited.The Ocular Surface Disease Index questionnaire; tear film assessment encompassing tear meniscus height and non-invasive keratograph breakup time ; meibography score,corneal fluorescein staining; the Schirmer I test ; expressible meibomian gland, and quality ,anterior and total corneal aberrations were evaluated before and after treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Meibomian Gland Dysfunction

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * tear break-up time (BUT) ≤10 seconds or Schirmer I test (SIT) ≤10 mm, the presence of dry eye symptoms, and fluorescein staining (FL) score \<3 points and at least one lid margin abnormality and poor meibomian gland expressibility Exclusion Criteria: * eyelid structure abnormal(Entropion , ectropion); * having received any other treatment for MGD within three months * history of ocular surgery * contact lens use * ocular infection * any type of corneal scarring

Locations (1)

Eye Hospital of Wenzhou Medical College

Wenzhou, Zhejiang, China

Outcomes

Primary Outcomes

corneal aberration corneal aberrations

Corneal aberrations were measured with a Pentacam。 The anterior corneal wavefront aberration was expanded with normalized Zernike polynomials.The corneal aberration from 3rd to 6th order were recorded as the root mean square (RMS) for analysis.

Time frame: baseline and 1 week after treatment

Data from ClinicalTrials.gov

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