Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects

Inclusion Criteria: * Male or female between 18 and 55 years of age (extremes included), on the date of signing the informed consent form. Female subjects should be of non-childbearing potential. * A body mass index between 18.0 and 30.0 kg/m2, inclusive. * Judged to be in good health by the investigator based upon: * The results of a medical history * Physical examination * Vital signs * Oxygen saturation * 12-lead electrocardiogram * Fasting clinical laboratory safety tests. Aspartate aminotransferase and alanine aminotransferase must be no greater than 1.5x upper limit of normal range and total bilirubin no greater than 1x upper limit of normal. Other clinical laboratory safety test results must be within the reference ranges or test results that are outside the reference ranges need to be considered not clinically significant in the opinion of the investigator. This list only contains the key inclusion criteria. Exclusion Criteria: * Known hypersensitivity to ingredients of GLPG4716 and/or MDZ * History of a significant allergic reaction to ingredients of GLPG4716 and/or MDZ as determined by the investigator. * Treatment with any medication including: * Over-the-counter and/or prescription medication * Dietary supplements * Nutraceuticals, vitamins and/or herbal supplements, and hormonal replacement therapy * Except occasional paracetamol (maximum dose of 2 g/day and maximum of 10 g/2 weeks) in the last 2 weeks or 5 half-lives of the drug, whichever is longer, prior to the first dosing. This list only contains the key exclusion criteria.