Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people. The aim of this randomized study was to determine whether intervention based on additional capnographic monitoring reduces the incidence of hypoxia in gastrointestinal endoscopes procedures for elderly patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
1,800
Standard monitoring and capnographic monitoring.
Standard monitoring but no capnographic monitoring
Henan Provincial People's Hospital
Zhenzhou, Henan, China
Qilu Hospital of Shandong University
Qingdao, Shandong, China
Renji Hospital
Shanghai, Shanghai Municipality, China
The incidence of hypoxia
(75% ≤ SpO2 \< 90% for \<60 s)
Time frame: Patients will be followed for the duration of hospital stay, an expected average of 2 hours
The incidence of sub-clinical respiratory depression
(90% ≤ SpO2 \< 95%)
Time frame: Patients will be followed for the duration of hospital stay, an expected average about 2 hours
The incidence of severe hypoxia
(SpO2 \< 75% or 75% ≤ SpO2 \< 90% for \>/=60 s)
Time frame: Patients will be followed for the duration of hospital stay, an expected average about 2 hours
The incidence of capnography curve decreased by half or more than the baseline and even disappeared without hypoxia
capnography curve decreased by half or more than the baseline and even disappeared, SpO2 \>90%
Time frame: Patients will be followed for the duration of hospital stay, an expected average about 2 hours
The incidence of other adverse events
Other adverse events recorded by tools proposed by the World Society of Intravenous Anesthesia International Sedation Task Force
Time frame: Patients will be followed for the duration of hospital stay, an expected average about 2 hours
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