The "Cardiovascular Risk Reduction-Diet in Pregnancy" (CARRDIP) - is a randomised controlled trial with dietary intervention during pregnancy. The participants were enrolled in Norway 20 years ago and consisted of 269 pregnant, healthy mothers. The participants were randomised 1:1 to either intervention-diet or control. The intervention diet was build upon an anti-atherogenic principle and was a so called "Mediterranean diet". The participants were monitored during pregnancy, and mother and child participated in a follow-up study 1 year after birth. The current "CARRDIP20" trial is a follow-up of the same participants, both mother and offspring, 20 years after the original intervention to measure and analyse the cardiovascular health and compare the intervention group to the control group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
538
Participants instructed in antiatherogenic diet during pregnancy with frequent follow-ups to ensure compliance
University of Oslo
Oslo, Norway
RECRUITINGCardiovascular health score
Cardiovascular risk score by use of the most appropriate available risk score algorithm available at time of analysis, at present the preferred calculator is Life's Simple 7 - The American Heart Association https://doi.org/10.1161/CIRCULATIONAHA.109.192703
Time frame: 1 day
Blood samples - Lipid profile
Ratio of non-HDL cholesterol to HDL cholesterol in blood
Time frame: 1 day
Blood samples - Lipid profile
Lipoprotein a concentration in blood
Time frame: 1 day
Anthropometry
Waist-to-hip ratio (WHR)
Time frame: 1 day
Body fat percentage
Measured by bioimpedance
Time frame: 1 day
Ultrasound examination of liver
Ultrasound-Guided Attenuation Parameter (UGAP) of liver
Time frame: 1 day
Ultrasound examination of carotid artery
Intima-media thickness in carotid artery
Time frame: 1 day
Blood samples - Glukose metabolism
Hemoglobin A1c concentration in blood as a measure of long term blood sugar levels
Time frame: 1 day
Mean arterial pressure (MAP)
Measured by
Time frame: 1 day
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