The SPINDLE study will examine sleep in infants with atopic dermatitis by serial assessment over the first year of life, in comparison to infants without atopic dermatitis. Sleep will be assessed using electroencephalography, actigraphy, and sleep questionnaires.
Infants will be recruited at 6 to 8 months and followed up until 18 months of age. Sleep electroencephalography will be performed at 6 to 8 months. Sleep actigraphy will be performed at 6 to 8 months and 12 months. Infant sleep questionnaires will be completed on a monthly basis, and parental sleep questionnaires will be completed at 6 to 8 months, 9 to 10 months, and 12 months. A neurodevelopmental assessment will be performed at 18 months.
Study Type
OBSERVATIONAL
Enrollment
100
INFANT
Cork, Ireland
RECRUITINGAltered macrostructure of sleep from 6 to 12 months measured with parental sleep diaries
Measured as decreased sleep efficiency and increased night time awakenings
Time frame: 6 months to 12 months
Altered macrostructure of sleep at 6 and 12 months measured by nocturnal actigraphy
Measured as sensor-detected movement
Time frame: 6 months, 12 months
Altered microstructure of sleep at six-eight months using electroencephalography to measure sleep spindle power in rapid eye movement and non-rapid eye movement stages
Measured as sleep spindle power and power in rapid eye movement (REM) and non-rapid eye movement (NREM) sleep stages
Time frame: 6-8 months
Parental sleep quality and quality of life measured using the Pittsburgh Sleep Quality Index (PSQI)
Measured using standardized questionnaire (PSQI)
Time frame: 6 months to 12 months
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