Antimicrobial photodynamic therapy (aPDT) is characterized by the association of photosensitizing agents, promoting the generation of reactive oxygen species like free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Simvastatin (SMV) enhances alkaline phosphatase activity and increases the expression of bone sialoprotein, osteocalcin, and type I collagen and is shown to have an anti-inflammatory effect by decreasing the production of C-reactive protein (CRP), IL-6, and IL-8. SMV is also reported to stimulate VEGF release in a dose-dependent manner which promotes osteoblast differentiation and bone nodule formation. The aim of this study is to evaluate the adjunctive effects of SMV with and without aPDT in chronic periodontitis patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
20
Application of SMV and antimicrobial photodynamic therapy in intrabony defects
Application of SMV without antimicrobial photodynamic therapy in intrabony defects
Faculty of Dentistry, Kafrelsheikh University
Kafr ash Shaykh, Egypt
RECRUITINGClinical evaluation and measurements of the defect in millimeters
Changes in clinical measurements after application of simvastatin with and without antimicrobial photodynamic therapy in millimeters
Time frame: 9 months
Radiographic evaluation and measurements of the defect in millimeters
Changes in bone formation in millimeters after application of simvastatin with and without antimicrobial photodynamic therapy in millimeters
Time frame: 9 months
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