The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay by multiparametric cardiac MRI.
The aim of the study is to demonstrate any differences in myocardial structure and function using multiparametric cardiac MRI in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay and subsequent convalescence compared to a control group with intensive care stay but without kidney injury. Furthermore, the correlation between clinical disease severity and cardiac involvement will be investigated.
Study Type
OBSERVATIONAL
Enrollment
40
Multiparametric cardiac magnetic resonance, including functional and structural parameter
University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology
Bonn, North Rhine-Westphalia, Germany
RECRUITINGUniversity Hospital Bonn, Department of Anesthesiology and Intensive Care Medicine
Bonn, North Rhine-Westphalia, Germany
RECRUITINGMyocardial T1 relaxation time
T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\].
Time frame: Measurement will be performed within 2 weeks after MRI scan.
Myocardial T2 relaxation time
T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in \[ms\].
Time frame: Measurement will be performed within 2 weeks after MRI scan.
Myocardial ECV
Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in \[%\].
Time frame: Measurement will be performed within 2 weeks after MRI scan.
Myocardial strain
Cardiac magnetic resonance feature-tracking will be used to asses left ventricular longitudinal, circumferential and radial strain.
Time frame: Measurement will be performed within 2 weeks after MRI scan.
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