A SBT-based Protocol-directed Program in Difficult-to-Wean Patients

JinyanXing200 enrolled

Overview

Weaning patients from a ventilator is one of the most challenging processes in an intensive care unit. The investigators aimed to determine whether spontaneous breathing trial (SBT)-based protocol-directed weaning combined with the high-flow nasal cannula (HFNC) could be superior to routine SBT-based weaning in reducing the duration of mechanical ventilation (MV) in difficult-to-wean patients.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

200

Conditions

Respiration, Artificial

Interventions

a weaning protocolPROCEDURE

a weaning protocol that is combined spontaneous breathing trial (SBT) with the high-flow nasal cannula (HFNC)

Eligibility

Sex: ALLMin age: 16 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age ≥ 16 years old * MV for more than 48 hours * intubated or tracheostomized Exclusion Criteria: * pregnancy * irreversible respiratory failure caused by neurodegenerative disorders, such as Alzheimer disease, motor neuron disease, or multiple system atrophy * pre-existing decision to limit life support * waiving of MV during treatment * terminal stage of severe illness

Locations (1)

The Affiliated Hospital of Qingdao University

Qingdao, Shandong, China

RECRUITING

Outcomes

Primary Outcomes

mechanical ventilation days

the duration of mechanical ventilation

Time frame: 60 days

Secondary Outcomes

re-intubated within 24 hours

Time frame: 24 hours

Central Contacts

Jinyan Xing, Doctor

CONTACT

86-0532-82919386 xingjy@qdu.edu.cn

Data from ClinicalTrials.gov

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