Evaluation of the Efficacy and Safety of a Hyaluronic Acid Gel in Adhesion Prevention After Open Thyroidectomy.

Inclusion Criteria: * Male and female between 20 and 70 years of age. * Patients diagnosed with benign goiter or thyroid cancer that will undergo open thyroidectomy (either unilateral or bilateral total thyroidectomy with or without central lymph node dissection). * Naïve patients to thyroid surgery. * Subjects are willing to comply with all aspects of the study and have signed informed consent form. Exclusion Criteria: * Pregnant or lactating female patients. * Presence of severe and uncontrolled illness such as stroke, hypertension, diabetes, chronic renal failure, coagulopathy, drug abuse. * Patients with previous neck radiotherapy within 1 year. * Concurrent diseases/conditions which will be unable to evaluate the outcomes. * Patients receiving any adhesion prevention adjuvant. * Previous history of Keloid or hypertrophic scar. * Anticoagulant used within a week from surgery. * Subjects are hypersensitive to sodium hyaluronate. * Participate in another clinical trial within 1 month. * Patients presence of surgical site infection. * Patients are with abnormal clinical test (appendix 1) result within one month or ECOG performance status (appendix 2) score ranged from 3-4.