To investigate the effect of liposomal bupivacaine compared with bupivacaine hydrochloride for intercostal blockades for patients undergoing Video-assisted thoracoscopic surgery.
Video-assisted thoracoscopic surgery (VATS) is a minimally invasive routine procedure. It's less invasive than thoracotomy but postoperative pain is still a problem. At Aalborg University Hospital, intercostal blockades with bupivacaine is used as standard pain treatment for patients undergoing VATS. Adding adjuvants to the blockades may prolong the effect. The aim of this study is to examine if intercostal nerve blockades with liposomal bupivacaine improves postoperative pain management compared to intercostal nerve blockades with bupivacaine hydrochloride.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
50
As prior described
As prior described
Aalborg University Hospital
Aalborg, Region of Northern Jutland, Denmark
Duration of analgesic effect
Time in hours to first postoperative administration of Pro Re Nata (PRN) opioids
Time frame: 48 hours
Total equipotent opioid dose
Total equipotent opioid dose in milligrams during the first 48 hours after surgery.
Time frame: 48 hours
Numerical Rating Scale
Pain intensity on a Numerical Rating Scale ranging from 0 indicating no pain to 10 indicating worst pain imaginable during the first two postoperative days.
Time frame: 48 hours
Mobilisation
Time in hours to full mobilisation defined as walking with or without aids.
Time frame: 48 hours
Opioids at discharge
Need for opioids at discharge (yes or no and equipotent dosage)
Time frame: Not fixed. On average 4 days and a maximum of 3 months.
Patient-reported satisfaction of postoperative pain management assessed by self-made questionnaire in Danish
Patients are asked to fill out a questionnaire rating their general satisfaction with pain management and sufficiency of pain treatment on a scale from 0 to 10. The questionnaire also assess whether the patients had any perceived side effects and how uncomfortable they were on a scale from 0 to 10.
Time frame: Measured twice. Once 48 hours after surgery and once at non fixed time(on average 4 days and a maximum of 3 months)
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