Releasing of Inflammatory Mediators During Retreatment of Root Canals

Bulent Ecevit University75 enrolled

Overview

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Inflammatory Response Root Canal Infection

Interventions

Protaper Universal RetreatmentOTHER

D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor

ReciprocOTHER

R25 retratment files were used with X-Smart endomotor in reciprocal motion

XP-Endo finisher ROTHER

XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor

Eligibility

Sex: ALLMin age: 18 YearsMax age: 68 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who had single root canal treated teeth with chronic periapical lesion Exclusion Criteria: * Patients who are immunocompromised * Patients under antibiotic or analgesic medication

Locations (1)

Faculty of Dentistry of Bulent Ecevit University

Zonguldak, Turkey (Türkiye)

Outcomes

Primary Outcomes

change of inflammatory mediator level

The samples were collected from periapical exudate at the end of the root canal retreatment procedure. The samples were analyzed with ELISA method and change of inflammatory mediator levels were evaluated in pg/ml.

Time frame: 24 hours

Data from ClinicalTrials.gov

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