Ablation of atrial fibrillation is standard therapy for symptomatic patients or patients with severely reduced systolic left ventricular ejection fraction. Complications of the procedure are ischemic thrombembolic stroke. Therefore periprocedural treatment with heparin is administered to acchieve a therapeutic anticoagulation. The efficacy of anticoagulation is measured by active-clotting time (ACT) which is measured with blood drawn mostly from the V. femoralis. Despite controlled anticoagulation periprocedural stroke is published with an incidence of up to 2% and asymptomatic cerebral embolization from 2% to 15%. The ACT-Trial has two aims: 1. Analysis of the influence of the localization of blood drawing on the measured ACT: blood from central venous line, from LA and from LAA. 2. Dependency of the ACT measured in the blood of the LAA with regard to anatomic und functional LAA-measurements. Patients will be included scheduled for left atrial ablation procedure and will be divided in two groups: atrial fibrillation at time of procedure and sinus rhythm at time of procedure.
Study Type
OBSERVATIONAL
Enrollment
190
Measurement of active clotting time (ACT)
Internistisches Klinikum München Süd
Munich, Bavaria, Germany
RECRUITINGComparison of mean and median values of ACT measurements from LA und LAA and dependency on anatomic and functional LAA parameters among patients in sinus rhythm.
Active clotting time from left atrium (LA) and left atrial appendage (LAA) measured at the same time.
Time frame: During ablation procedure
Target values of ACT measured in central venous line, LA and LAA among patients with sinus rhythm
Active clotting time from left atrium (LA) and left atrial appendage (LAA) measured with regard to target ACT over time during ablation procedure among patients with sinus rhythm.
Time frame: During ablation procedure
Target values of ACT measured in central venous line, LA and LAA among patients with atrial fibrillation
Active clotting time from left atrium (LA) and left atrial appendage (LAA) measured with regard to target ACT over time during ablation procedure among patients with atrial fibrillation.
Time frame: During ablation procedure
Dynamics of ACT values over time from samples taken from central venous line, LA and LAA among patients with sinus rhythm
Active clotting time from left atrium (LA) and left atrial appendage (LAA) measured with regard to time behaviour during ablation procedure among patients with sinus rhythm.
Time frame: During ablation procedure
Dynamics of ACT values over time from samples taken from central venous line, LA and LAA among patients with atrial fibrillation
Active clotting time from left atrium (LA) and left atrial appendage (LAA) measured with regard to time behaviour during ablation procedure among patients with atrial fibrillation.
Time frame: During ablation procedure
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