To determine the role of antibiotic prophylaxis in the surgical management of miscarriage.
Patients will be randomized to receive either prophylactic antibiotic \[a single dose of oral doxycycline (200 mg) and metronidazole (500 mg)\] or placebo using identical sealed envelopes.Included cases are those with early miscarriage (within the first trimester 12 6/7 weeks of gestation) , missed or incomplete miscarriage, undergoing surgical management will be included in the study. Technique: The investigators will prepare 138 identical envelops, half of them filled with a label group(1) who are the group to receive the antibiotic prophylaxis with all instruction details, while the other half filled with a label identifying ( group 2) who are the placebo group. All envelops will be prepared by the investigator and sealed before starting enrollment. After enrollment, each participant will be allowed to choose one envelop to determine to which group the patient will be assigned to.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
138
Group 1; receiving antibiotic prophylaxis; single dose of oral doxycycline (200 mg) tablet and metronidazole (500 mg) tablet 2 hours before the surgical evacuation Group B ;receiving placebo 2 hours before the surgical evacuation
Department of Obstetrics and Gynecology, Kasr Al-Ainy University Hospital, Cairo University.
Cairo, Egypt
RECRUITINGChange of pelvic infection after surg ical evacuation of miscarriage with use of antibiotic prophylaxis.
White cell count \>12 \*10\^9 cells / L by CBC
Time frame: 2 weeks from surgery
Change in the risk of severe puerperal sepsis following the surgical procedure
Signs of puerperal sepsis in form of puerperal pyrexia \>38 C and/or purulent vaginal discharge
Time frame: 2 weeks from surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.