Phase 3 Study to Evaluate the Lot Consistency of a Recombinant Coronavirus-Like Particle COVID-19 Vaccine

Inclusion Criteria: * Male and female subjects must be 18 - 49 years of age at screening visit. * Subjects must have a body mass index \< 35 kg/m2 at screening visit. * Subjects must be in good general health prior to study participation. Note: Subjects with a pre-existing chronic disease will be allowed to participate if the disease is stable and the condition is unlikely to confound the results of the study or pose additional risk to the subject. * Female subjects of childbearing potential must have a negative urine pregnancy test result prior to vaccination. * Female subjects of childbearing potential must use a highly effective method of contraception starting one month prior to vaccination, continuing until the end of the study, and must not plan to become pregnant for at least one month after her last study vaccination. Exclusion Criteria: * Significant acute or chronic, uncontrolled medical or neuropsychiatric illness. * Any confirmed or suspected current immunosuppressive condition or immunodeficiency, including cancer, human immunodeficiency virus (HIV), hepatitis B or C infection (subjects with a history of cured hepatitis B or C infection without any signs of immunodeficiency at present time are allowed). * Current autoimmune disease (such as rheumatoid arthritis, systemic lupus erythematosus or multiple sclerosis). * Administration of any medication or treatment that may alter the vaccine immune responses, such as: * Systemic glucocorticoids at a dose exceeding 10 mg of prednisone (or equivalent) per day for more than seven consecutive days or for 10 or more days in total, within one month prior to the Vaccination visit (Visit 2). Inhaled, nasal, ophthalmic, dermatological, and other topical glucocorticoids are permitted. * Cytotoxic, antineoplastic, or immunosuppressant drugs - within 36 months prior to Vaccination (Visit 2). * Any immunoglobulin preparations or blood products, blood transfusion - within 6 months prior to Vaccination (Visit 2). * Administration of any vaccine within 14 days prior to Vaccination (Visit 2); planned administration of any vaccine during the study (up to Day 28 of the study). * Administration of any other SARS-CoV-2 / COVID-19, or other experimental coronavirus vaccine at any time prior to or during the study. * History of virologically-confirmed COVID-19. * Use of any investigational or non-registered product within 30 days or 5 half-lives, whichever is longer, prior to Vaccination (Visit 2) or planned use during the study period. * Have a rash, dermatological condition, tattoos, muscle mass, or any other abnormalities at injection site that may interfere with injection site reaction rating. * Use of any prescription antiviral drugs with the intention of COVID-19 prophylaxis, including those that are thought to be effective for prevention of COVID-19 but have not been licensed for this indication, within one month prior to Vaccination (Visit 2). * History of a serious allergic response to any of the constituents of CoVLP including AS03. * History of a documented anaphylactic reactions to plants or plant components (including tobacco, fruits and nuts). * Personal or family (first-degree relatives) history of narcolepsy. * Subjects with a history of Guillain-Barré Syndrome. * Any female subject who has a positive or doubtful pregnancy test result prior to vaccination or who is lactating.