This study is designed to find out how smoking affects the way the brain responds to pleasure and how this impacts smokers' behavior. Participants will complete three sessions. The first session will be a screening and training visit to determine final eligibility. Eligible participants will work with a researcher to develop brief scripts about times when they smoke and do other activities. Next, participants will attend two magnetic resonance imaging (MRI) scans - one after abstaining from smoking for 24 hours and the other after smoking as usual. After the second MRI, participants will answer questions on their phone every day for two weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
58
Participants will abstain from smoking for 24 hours
Participants will continue smoking as usual (i.e. ad lib) in the day leading up to the scan and smoke one cigarette of their own brand immediately prior to scanning.
Hardesty Center for Clinical Research and Neuroscience
Tulsa, Oklahoma, United States
Blood Oxygen Level Dependent (BOLD) Activation
BOLD activation in brain reward network regions
Time frame: Approximately 2-4 weeks
Ecological Momentary Assessment (EMA) Pleasure Ratings
Anticipated and experienced pleasure based on self-report ratings acquired each day during the EMA phase
Time frame: 2-4 weeks
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