Therapeutic plasma exchange (TPE) has been shown to be an important procedure for treatment of a variety of refractory immune complex disorders, such as Guillain-Barré syndrome and neuromyelitis optica. The intervention removes plasma, albumin, or some other substance. Meropenem is a broad-spectrum beta-lactam antimicrobial agent that is used for the treatment of serious nosocomial infections. Pathophysiological changes in patients on TPE can alter the pharmacokinetic (PK) patterns of coadministered antibiotics. This effect has an impact on the antimicrobial agents when paticipants are administered during the intervention. The aim of this study was to investigate the impact of TPE on meropenem PK.
Study Type
OBSERVATIONAL
Enrollment
15
each patient received a 1 hour infusion of a single dose of 1 g of meropenem diluted in 100 ml of normal saline solution, at the same time as the start of the first TPE and meropenem PK studies were carried out after the administration of meropenem. Blood samples (3 ml) were obtained by direct venipuncture at the following times: shortly before (time zero) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6 and 8 hours after the start of the meropenem administration.
Faculty of Medicine, Prince of Songkla University, Thailand
Hat Yai, Changwat Songkhla, Thailand
RECRUITINGThe plasma concentrations were measured at the following times: 0, 0.25, 0.5, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6 and 8 hour after the start of drug administration
Time frame: 0-8 hours after the drug administration
Maximum plasma concentration [Cmax]
Time frame: 0-8 hours after the drug administration
Minimum plasma concentration [Cmin]
Time frame: 0-8 hours after the drug administration
Area under the plasma concentration versus time curve [AUC]
Time frame: 0-8 hours after the drug administration
half-life [t1/2]
Time frame: 0-8 hours after the drug administration
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