Effect of PRP as Therapy for Shoulder Osteoarthritis

Ain Shams University91 enrolled

Overview

Patients with shoulder osteoarthritis are suffering from pain and disabilities which lead to difficulties in life. The presence of platelet-rich plasma as regenerative therapy which helps in healing of damaged tissues like ligaments and joint might be of great benefit in managing such conditions.

Primary and secondary osteoarthritis of the shoulder occurs due to destruction of the articular surface of the humeral head and glenoid , Patient mainly presented with pain and decreases in the range of motion . Treatment of shoulder osteoarthritis is often controversial and is typically based on the patient's age, the severity of symptoms, and level of activity, radiographic findings, and medical comorbidities. The new era of management include regenerative therapy ,Platelet-rich plasma (PRP) is one of the regenerative therapy that prove its effect as injections of a concentration of a patient's own platelets to accelerate the healing of injured tendons, ligaments, muscles and joints.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Shoulder Osteoarthritis

Interventions

Injection in the intraarticular space of glenohumeral jointPROCEDURE

U/S guided injection of platelet rich plasma (PRP) or normal saline (NS)

Eligibility

Sex: ALLMin age: 21 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patient's age: From 21 years. * Acute symptoms on a background of at least a 3-month history of chronic pain or swelling of the shoulder joint with radiological confirmed (X-ray or MRI) * Mild or moderate osteoarthritis of the shoulder joint according to The Samilson-Prieto classification. * Numerical Rating Scale for pain scores greater than five on a 10 scale Exclusion Criteria: * Under 21 years of age * Severe osteoarthritis according to The Samilson-Prieto classification. (Figure 1) * Neuropsychiatric disorders. * Immunocompromised patients. * Active infection or malignancy at the joint. * Pregnancy and breastfeeding. * Patients may have thrombocytopenia, bleeding disorders, or on anticoagulant therapy. * Shoulder surgery within 3 months or inflammatory arthritis; previous infection of the shoulder joint.

Locations (1)

Ainshams University

Cairo, Egypt

Outcomes

Primary Outcomes

Change in patient's pain score

By using NUMERICAL PAIN SCALE patient will mention them pain score on scale from 1 to 10, where the pain score to be included in the study is 5 and more , we will measure pain score for each patient after 2 weeks from injection ,where decrease of the number from the initial recorded number before injection means improvement.

Time frame: 2 weeks after each injection

Secondary Outcomes

change in the range of motion

This out come will be evaluated by physiotherapist using a device called a goniometer. A goniometer is a metal or plastic handheld device with two arms. Numbers representing angular distance are on the device, The physiotherapist measures the initial angular distance before the injection, and after the injection by 2 weeks Normal range of active movement of the shoulder has been specified by the American Academy of Orthopedic Surgeons (AAOS) to be 180° for flexion and abduction and 90° for external rotation.

Time frame: 2 weeks after each injection

Data from ClinicalTrials.gov

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