Hypoparathyroidism is the most frequent complication in total thyroidectomy. The use of near-infrared autofluorescence (NIRAF) intraoperatively, seems to reduce the rate of transient hypoparathyroidism. Unfortunately, no effect on permanent hypoparathyroidism has been shown. In order to cover every aspect of the impact of NIRAF in thyroid surgery, an evaluation in low-volume, non-parathyroid institutions is needed. This is the overall aim of our current studies. The objective of this specific study is to evaluate the impact of NIRAF on immediate, transient and permanent hypoparathyroidism following total thyroidectomy in low-volume, non-parathyroid institutions.
Patients referred for total thyroidectomy will undergo NIRAF-assisted surgery (Fluobeam LX) at two low-volume ENT-departments with no experience in parathyroid surgery. PTH and ionized calcium will be assessed preoperatively, on postoperative day 1 (POD1) and minimum two months following surgery. Patients who still fulfill the criteria for hypoparathyroidism at that point will be followed until one year following surgery. The rates of immediate, transient and permanent hypoparathyroidism will be assessed and compared to a historic cohort.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
78
See arm description
Department of Otorhinolaryngology, Hospital South West Jutland
Esbjerg, Denmark
Department of Otorhinolaryngology, Regional Hospital West Jutland
Holstebro, Denmark
Rate of hypoparathyroidism
Time frame: Will be assessed on postoperative day one, minimum two months and one year following surgery.
Parathyroid gland identification rate
Time frame: Will be assessed at the time of surgery
Parathyroid autotransplantation rate
Time frame: Will be assessed at the time of surgery
Rate of inadvertently excised parathyroid glands
Time frame: Will be assessed 1 month following surgery
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