The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis

Kafrelsheikh University20 enrolled

Overview

Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

L-PRF Photodynamic Therapy Aggressive Periodontitis

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * systemically healthy * non- smoker, * not received any periodontal treatment within the last 6 months, * no antibiotics, anti- inflammatory drugs or any other medication taken within the last 6 months Exclusion Criteria: * any systemic disease that might influence the prognosis of periodontal disease and outcome of the treatment, * any medical condition that required antibiotic prophylaxis before the treatment, * smoking, * pregnancy and lactation, * ingestion of antibiotics, anti-inflammatory drugs or any other medication during the study period, * any physical limitations or restrictions that might preclude normal oral hygiene procedures.

Outcomes

Primary Outcomes

Clinical evaluation and measurements of the defect in millimeters

Changes in clinical measurements in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF

Time frame: 9 months

Radiographic evaluation and measurements of the defect in millimeters

Changes in bone formation in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF