Hemoperfusion in Critical Patients With Septic Multiorgan Dysfunction Syndrome.

Hospital Clinic of Barcelona48 enrolled

Overview

Low-level interventional clinical trial to evaluate the effectiveness and safety of extracorporeal support with hemoperfusion in critical patients with septic multiorgan dysfunction syndrome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Hemoperfusion Multiorgan Failure Sepsis

Interventions

Extracorporeal support with haemoperfusionPROCEDURE

Use of extracorporeal support with haemoperfusion

Conventional treatmentPROCEDURE

Conventional treatment

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with a sepsis diagnosis, according to the diagnostic criteria of the International Sepsis-3 Consensus Conference, and without response to the treatment of septic shock who meet the following conditions: * Sepsis of abdominal origin with controlled infectious focus. * Noradrenaline dose\> 0.5 µg / kg / min to maintain adequate organ perfusion after optimization of fluid therapy. * Dysfunction of two or more organs with SOFA ≥ 9 (5). * Blood lactate ≥ 2 mmol / L. * Procalcitonin (PCT)\> 10 ng / mL. * CRP\> 100 mg / L. * IL-6\> 2000 pg / ml. Exclusion Criteria: * Age under 18 years or over 80 years. * Pregnancy or breastfeeding. * Terminally ill patients or with a life expectancy of less than 48 hours. * Thrombocytopenia \<60,000 / mm3. * Pancytopenia. * Severe coagulopathy with high risk of bleeding. * Inclusion in another research protocol. * In case of re-entry during the study period, only the first admission will be included. * Use of another haemoperfusion device.

Locations (1)

Hospital General Universitario de Castellon

Castellon, Castellón, Spain

RECRUITING