Risk Factors of Perforated HSCR in Neonates

Tongji Hospital600 enrolled

Overview

Hirschsprung's disease (HSCR) is a common digestive malformation with radiographic evidence of distal bowel obstruction and clinical signs of abdominal distension, vomiting, constipation, and failure to pass meconium. Bowel perforation (perforated HSCR) is a very serious complication of HSCR, but if this occurs it is most often in the neonatal period. The current study collected information on all cases diagnosed with perforated HSCR from multi-centers in China over 10 years, the aim was to evaluate the clinical features of perforated HSCR, and investigate possible risk factors for perforated HSCR in neonates.

Study Type

OBSERVATIONAL

Enrollment

600

Conditions

Hirschsprung Disease Bowel; Perforation, Fetus or Newborn

Interventions

Emergency surgical enterostomyPROCEDURE

Emergency surgical enterostomy

Eligibility

Sex: ALLMin age: 0 DaysMax age: 30 Days

Medical Language ↔ Plain English

Inclusion Criteria: * Neonates (≤1 month age) * Diagnosed with HSCR * Suffered with bowel perforation Exclusion Criteria: * Patients complicated with suspected necrotizing enterocolitis (NEC), imperforate anus (IA), intestinal atresia, and meconium plug syndrome * Neonates who transferred from outside participating hospitals.

Outcomes

Primary Outcomes

Rate of bowel perforation in neonatal Hirschsprung disease (perforated HSCR)

Cases with bowel perforation in neonatal Hirschsprung disease/ total neonatal Hirschsprung disease

Time frame: 14 years

Data from ClinicalTrials.gov

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