Efficacy of Apraclonidine Eye Drops in the Treatment of Ptosis Secondary to Myasthenia Gravis

American University of Beirut Medical Center10 enrolled

Overview

This study is aimed at assessing the efficacy of Apraclonidine eye drops in the treatment of ptosis secondary to myasthenia gravis.

The rationale behind using Apraclonidine is that it acts on Muller's muscle which is a sympathetic-innervated muscle. As such, this muscle is expected to be spared from the effects of the autoantibodies that attack the postsynaptic portion of the neuromuscular junction in myasthenia gravis.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Myasthenia Gravis Ocular Myasthenia Gravis

Interventions

Apraclonidine Hcl 0.5% Oph SolnDRUG

Each patient is administered 2 drops of Apraclonidine 0.5% solution to the most affected eye

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18 or older with a diagnosis of ocular or generalized myasthenia gravis with ocular involvement. Exclusion Criteria: * Patients receiving mono-amino-oxidase inhibitors. * Patients with history of hypertension, cardiac, or cerebrovascular disease. * Women with confirmed pregnancy.

Locations (1)

American University of Beirut Medical Center

Beirut, Lebanon

Outcomes

Primary Outcomes

Change in palpebral fissure height (PF)

Change in PF measurements

Time frame: Before administration, at 1, 5, 30, and 60 minutes after administration

Change in marginal reflex distance-1 (MRD1)

Change in MRD1 measurements

Time frame: Before administration, at 1, 5, 30, and 60 minutes after administration

Change in marginal reflex distance-2 (MRD2)

Change in MRD2 measurements

Time frame: Before administration, at 1, 5, 30, and 60 minutes after administration

Change in levator function (LF)

Change in LF measurements

Time frame: Before administration, at 1, 5, 30, and 60 minutes after administration

Data from ClinicalTrials.gov

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