Safety and Efficacy of Curcumin in Children With Acute Lymphoblastic Leukemia

Ain Shams University30 enrolled

Overview

Assessment of of the biological effects of curcumin on microbiota in children with acute lymphoblastic leukemia

Assessment of the safety of curcumin, which is the most active constituent of the ground rhizome of the Curcuma longa plant, in children with acute lymphoblastic leukemia patients (ALL) in maintenance phase of chemotherapy through the assessment of the any reported adverse event (AE). And assessment of the curcumin effect on health by eliminating intestinal microflora dysbiosis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Acute Lymphoblastic Leukemia, Pediatric

Interventions

CurcuminDRUG

Tumeric curcumin 500 mg per oral capsule of Puritans Pride company supplement

Standard of CareDIETARY_SUPPLEMENT

As per institution protocol for Standard of nutritional Care

Eligibility

Sex: ALLMin age: 1 YearMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Children aged from 1 year to 18 years Children with proven ALL diagnosed by bone marrow aspirate and immunephenotyping Patients in the maintenance phase week1 Exclusion Criteria: Children with other maliganacies, Current use (past use of these medications is not an exclusion) of medications or over-the-counter treatments including to sulfasalazine, warfarin, clopidogrel, aspirin, antacids, botanical treatments (ginger, feverfew, yellow clover, Salix species, Populus species, Betula species, and Gaultheria species), essential fatty acids (flax oil and fish oil).

Locations (1)

Pediatric Hematology Oncology and BMT Unit, Faculty of Medicine Ain Shams University

Cairo, Non-US, Egypt

Outcomes

Primary Outcomes

Determine the Safety of curcumin in pediatric patients with ALL.

Percentage of patients who developed adverse event

Time frame: 4 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.