Effects of Non-invasive Neuromodulation on Food Desire, Chewing Pattern, Executive Functions and Oxidative Stress.

Universidade Federal do Piauí36 enrolled

Overview

From the change in self-regulation, memory is inhibited, allowing individuals to suppress or ignore unwanted or outdated associations and thus help to filter information relevant to dietary goals from irrelevant information. Provoking changes in neuroplasticity and cortical excitability contribute to the regulation of neural activity. Both could be modified by applying direct electrical current to the sensorimotor cortex, with polarity/current-dependent results, and their effect would last for hours after the end of stimulation. Transcranial Direct Current Stimulation (tDCS), translated into Portuguese as Estimulação Transcraniana por Corrente Contínua (ETCC) is a neuromodulating tool in which a low-intensity electrical current is applied to the scalp to modulate neuronal activity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Craving Mastication Disorder Memory Disorders Executive Dysfunction

Eligibility

Sex: ALLMin age: 18 YearsMax age: 59 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * being a health professional at the HU-UFPI (higher and technical levels); * both sexes; * Age between 20 and 59 years old. Exclusion Criteria: * Participants with communication disabilities (outbound or inbound); * Type 1 and 2 diabetes * low Body Mass Index (BMI; below 18.5), * intracranial metal clip and/or prostheses; * Abrupt change in weight (\> 5 kg) in the last six months; * the use will be excluded recreational use of psychoactive drugs, * Being a smoker or using nicotine (tablet / absorbent), * Having had significant recent trauma or traumatic brain injury, * Present history of epilepsy, * to be pregnant or under suspicion * Missing teeth; * Medical diagnosis of eating disorder or any psychiatric disorder, * Having or having had cancer, * Diagnosis of heart disease.

Outcomes

Primary Outcomes

change in desire to consume food.

Questionnaires of Intense Food Desires - Trait (QDIC-T) validated for Brazilian Portuguese. The higher the score, the greater the amount of food craving presented.The QDIC-T scale is done on a 6-point scale with scores ranging from 39 to 214 points.

Time frame: pre-intervention.

change in desire to consume food.

Questionnaires of Intense Food Desires - Trait (QDIC-T) validated for Brazilian Portuguese. The higher the score, the greater the amount of food craving presented. The QDIC-T scale is done on a 6-point scale with scores ranging from 39 to 214 points.

Time frame: post-intervention (immediately after the end of study participation).

change in the executive brain functions - working memory

Trial Making Test (A and B). Assessments with single measurements (measurement of time, in seconds, to perform the test). the measurement unit for evaluating the outcome of these tests will be the amount of errors presented and the execution time (in seconds). The shorter the time and fewer errors, the better the result.

Time frame: pre-intervention.

change in the executive brain functions - cognitive flexibility

Stroop Tests. Assessments with single measurements (measurement of time, in seconds, to perform the test). the measurement unit for evaluating the outcome of these tests will be the amount of errors presented and the execution time (in seconds). The shorter the time and fewer errors, the better the result.

Time frame: post-intervention (immediately after the end of study participation).

Secondary Outcomes

change in the final value of inflammation scores

inflammation markers (PCR in serum). The biochemical dosage of all elements will be in mg/L, higher values will represent a higher concentration, that is, a greater degree of inflammatory processes.

Time frame: pre-intervention.

change in the final value of inflammation scores

inflammation markers (PCR in serum). The biochemical dosage of all elements will be in mg/L, higher values will represent a higher concentration, that is, a greater degree of inflammatory processes.

Time frame: post-intervention (immediately after the end of study participation).

change in the final value of antioxidant activity

antioxidant activity (Catalase in erythrocytes). The biochemical dosage of all elements will be in mg/L, higher values will represent a higher concentration, that is, a greater degree of inflammatory processes.

Time frame: pre-intervention.

change in the final value of antioxidant activity

Time frame: post-intervention (immediately after the end of study participation).

change in desire to consume food.

Questionnaires of Intense Food Desires - State (QDIC-E); validated for Brazilian Portuguese. QDIC-E is made up of a five-point scale, ranging from 15 to 75 points. The higher the score, the greater the amount of food craving presented.

Time frame: pre-intervention.

change in desire to consume food.

Questionnaires of Intense Food Desires - State (QDIC-E); validated for Brazilian.Portuguese. The higher the score, the greater the amount of food craving presented. QDIC-E is made up of a five-point scale, ranging from 15 to 75 points.

Time frame: post-intervention (immediately after the end of study participation).

Effects of Non-invasive Neuromodulation on Food Desire, Chewing Pattern, Executive Functions and Oxidative Stress.

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes