Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care

Inclusion Criteria: * 18-89 years old * Diagnosed with diabetes Mellitus; hemoglobin A1C \< 12% * Diabetic foot ulcer present for minimum 30 days (Wagner grade 1 or 2 classification) * Wound drainage is minimal or moderate * No clinically active wound infection * Able and willing to provide consent * Has not participated in another research trial within 3 months of enrollment. Exclusion Criteria: * Unable to keep weekly research appointments * Unable or unwilling to use offloading device if recommended * Wounds with large amount (high) drainage * Active gangrene * Wounds impending surgical intervention (including revascularization or plastic surgery) * Untreated osteomyelitis * Soft tissue infection (can be enrolled once infection is cleared) * Active Charcot arthropathy * BMI \>45kg/m2 * History of AIDS * History of organ transplant or impending transplant * End stage renal disease requiring dialysis * Decompensated hepatic or cardiac disease * Select autoimmune diseases * Lymphedema * Oral steroid use in last 3 months * Venous stasis disease * Active malignancy (cancer) * Unable to sign consent * Active alcohol or substance abuse * Pregnant or lactating women * Insufficient vascular flow to heal a wound * Hemoglobin A1C \>12%