A prospective observational study to identify different extrapulmonary clinical manifestations of SARS-CoV-2 and its correlations with the disease severity grades.
The current research in this area was retrospective trials; this study is a prospective one. Investigators will perform the extensive recording of extrapulmonary manifestations in adult patients of SARS-CoV-2 and their correlations with the disease severity grades. Type of the study: a prospective observational study Study Setting: Data will be collected from outpatients and inpatients files and a questionnaire. Sample Size Calculation: Depending on the average monthly (40-50 cases) and type of the study : -Investigators will use Steven K. Thompson equation 13 to calculate the size from the next formula Population size =(752) Sample size = (414) Level of confidence: ( 95%) Error proportion: (0.05) Probability :(20 %) Study power: (80 %)
Study Type
OBSERVATIONAL
Enrollment
445
Assiut University Hospital
Asyut, Egypt
Number of participants who has one or more of the following extrapulmonary clinical manifestations of SARS-CoV-2 .
Cardiovascular : * Coronary Artery Disease * Infarction (type 2) * Myocarditis * Arrhythmia * Cardiogenic shock * Heart failure Gastrointestinal : * Anorexia * Diarrhea * Bleeding * Digestive symptoms * Abnormal liver tests Neurological : * Headache * Impaired consciousness * acute ischemic stroke * Ataxia * Dizziness * Seizure * Taste impairment * Smell impairment * Vision impairment * Viral encephalitis * Depression Endocrinal: * Hypoglycemia * Ketoacidosis * Hyperglycemia * Thyrotoxicosis * Secondary Adrenal Insufficiency Hematological: * Leukocytosis * Leukopenia * Thrombocytopenia * Anemia * Lymphocytosis * D-dimer * Lactate dehydrogenase * Ferritin Renal : * Albuminuria * Hematuria * Blood urea nitrogen * Acute kidney injury Ophthalmologic : -Conjunctivitis Dermatologic : * Papulovesicular rash * Rosacea * Dryness * Erythema * Urticaria * Maculopapular exanthem morbilliform
Time frame: one year
The correlations between the number of participants who has extrapulmonary manifestations and the severity grade of SARS-CoV-2.
These correlations between the number of participants who has one or more of extrapulmonary manifestations and the severity of SARS-CoV-2, will be measured. There are four severity grades of SARS-CoV-2 according to WHO classifications (mild, moderate, severe and critical)
Time frame: one year
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