Myocardial Fibrosis and Inflammation in Liver Cirrhosis

University Hospital, Bonn13 enrolled

Overview

The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients with liver cirrhosis after implantation of transjugular intrahepatic portosystemic shunt (TIPS).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cirrhosis, Liver Cardiomyopathies Portal Hypertension

Interventions

Transjugular intrahepatic portosystemic shunt implantationPROCEDURE

Transjugular intrahepatic portosystemic shunt is an artificial channel within the liver that establishes communication between the inflow portal vein and the outflow hepatic vein. It is used to treat portal hypertension (e.g., in liver cirrhosis)

Magnetic resonance imagingDIAGNOSTIC_TEST

Multiparametric cardiac and hepatic magnetic resonance imaging

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria: * liver cirrhosis with evaluation of TIPS implantation * patients who are 18 years of age or older Exclusion criteria: * underlying cardiac disease, e.g. known myocardial infarction, previous myocarditis, congenital heart disease, cardiomyopathies of other causes known underlying disease witt potential cardiac involvement, e.g. storage disease (e.g. hemochromatosis, Fabry disease), inflammatory (e.g. sarcoidosis), endocrinological (e.g. diabetes mellitus, hyper-/hypothyroidism), autoimmune (e.g. systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis), therapeutic (chemotherapy). * patients with contraindication for contrast-enhanced MRI * pregnant and breastfeeding women

Locations (2)

University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology

Bonn, North Rhine-Westphalia, Germany

University Hospital Bonn, Medical Clinic and Polyclinic I

Bonn, North Rhine-Westphalia, Germany

Outcomes

Primary Outcomes

Myocardial T1 relaxation time

T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\].

Time frame: Change after 1 year of transjugular intrahepatic portosystemic shunt insertion.

Secondary Outcomes

Myocardial T2 relaxation time

T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in \[ms\].

Time frame: Change after 1 year of transjugular intrahepatic portosystemic shunt insertion.

Myocardial ECV

Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in \[%\].

Time frame: Change after 1 year of transjugular intrahepatic portosystemic shunt insertion.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.