GPC3 Targeted Fluorescence Image Guided Surgery of Hepatocellular Carcinoma

Chinese Academy of Sciences60 enrolled

Overview

This study is to evaluate whether intraoperative fluorescence imaging targeting GPC3 can aid improve the surgical accuracy of hepatocellular carcinoma. The main purposes of this study include: ① To raise the detection rate of hepatocellular carcinoma intraoperatively using the novel NIR-II fluorescence molecular imaging and the GPC-3 targeted fluorophore. ② To validate the safety and effectiveness of the designed GPC-3 targeted fluorophore for clinical application.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Hepatocellular Carcinoma

Interventions

Anti-GPC3-IRDye800CWDRUG

Drug Injection: Anti-GPC3-IRDye800CW

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients who have been diagnosed with hepatocellular carcinoma. 2. Planned to receive hepatectomy. 3. Liver function Child-Pugh A/B. 4. GPC-3 was validated highly expressed preoperatively. 5. Aged 18 to 75, and the expected lifetime is longer than 6 months. 6. Approved to sign the informed consent. Exclusion Criteria: 1. Allergic to IRDye800. 2. Enrolled in other trials in the past 3 months. 3. Another malignant tumor was found. 4. Undesirable function of heart, lung, kidney, or any other organs. 5. Unable to tolerate a hepatectomy. 6. The researchers considered inappropriate to be included.

Locations (2)

Zhuhai People's Hospital

Zhuhai, Guangdong, China

RECRUITING

The Affiliated Hospital of Southwest Medical University

Luzhou, Sichuan, China

RECRUITING

Outcomes

Primary Outcomes

HCC lesions

Numbers of intraoperatively detected hepatocellular carcinoma lesions.

Time frame: During hepatocellular resection surgery.

Central Contacts

Zeyu Zhang, Ph.D.

CONTACT

86-18201082715 zhangzeyu@fingerpass.net.cn

Data from ClinicalTrials.gov

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