Evaluation of Tofacitinib in Prevention of Photosensitivity in Lupus

Inclusion Criteria: 1. Cutaneous lupus erythematosus based upon all of the following: 1. a clinical diagnosis made by a rheumatologist or dermatologist of one of the following: acute cutaneous lupus erythematosus, subacute cutaneous lupus, or chronic cutaneous lupus erythematosus; 2. active skin disease within 5 years prior to screening. Participants may have concomitant SLE. 2. SLEDAI-2K score ≤4 (clinical criteria only, excludes all laboratory criteria) for all participants regardless of whether they have concomitant SLE. 3. If taking oral corticosteroids, the dose must be ≤ 10 mg daily of prednisone (or equivalent), stable dose for at least 4 weeks, and not anticipated to change over the course of the study. 4. If taking oral anti-malarial medications, the dose(s) must be ≤ 100 mg daily for quinacrine or/and ≤ 400 mg daily for hydroxychloroquine, stable for at least 6 months, and not anticipated to change over the course of the study. 5. If taking oral or subcutaneous methotrexate, the dose must be ≤ 25 mg weekly, stable for at least 4 weeks, and not anticipated to change over the course of the study. 6. If taking oral leflunomide, the dose must be ≤ 20 mg daily, stable for at least 4 weeks, and not anticipated to change over the course of the study. 7. If taking oral mycophenolate mofetil (MMF) or mycophenolic acid, the dose must be equivalent to ≤ 3000 mg of MMF daily, stable for at least 4 weeks, and not anticipated to change over the course of the study. 8. Adults 18 to 65 years of age at screening. 9. All participants and/or their sexual partners who engage in sexual activity that could lead to pregnancy must be willing to use complete abstinence or an FDA-regulated form of contraception for the duration of the study and for at least one month after discontinuation of study drug to prevent pregnancy. Highly effective birth control methods include, but are not limited to, hormonal contraception, an intrauterine device, or surgical options. Periodic abstinence and withdrawal are not acceptable methods of birth control. Exclusion Criteria: 1. Inability or unwillingness of a participant to give written informed consent or comply with study protocol. 2. Current or recent history, within the last year, of uncontrolled clinically significant renal, hepatic, hematologic, gastrointestinal, metabolic, endocrine, pulmonary, cardiac, or neurologic disease or significant impairment that might negatively impact the participant's ability to participate or that may put a participant at increased risk. 3. Potential active nephritis and/or urinary tract infection at screening, defined as any one of the following determined at screening unless otherwise specified: 1. \>10 RBCs /hpf, 2. \>5 WBCs /hpf with either positive nitrites or greater than a trace leukocyte esterase, 3. Signs or symptoms of a urinary tract infection, 4. For individuals with no history of nephritis: Urine protein (mg/dL): creatinine (mg/dL) ratio (Pr/Cr)\>0.5 at screening or a Pr/Cr level that has exceeded 1.0 in the prior 12 months, 5. For individuals with a history of nephritis: A rise in Pr/Cr of \>0.5 over the prior 3-6 months prior to screening. 4. History of severe gastrointestinal narrowing or strictures. 5. Medically confirmed history of diverticulitis or chronic, ulcerative lower gastrointestinal (GI) disease such as Crohn's disease, ulcerative colitis, or other symptomatic, lower GI conditions that might predispose a participant to perforations. 6. History of thrombosis, pulmonary embolism, or antiphospholipid syndrome. 7. History of any one of the following anti-phospholipid antibodies: 1. Positive lupus anticoagulant test, or 2. Anti-β2-glycoprotein I IgG ELISA titer ≥ 40 GPL, or 3. Anti-cardiolipin IgG ELISA titer ≥ 40 GPL. 8. History of chronic pulmonary disease requiring supplemental oxygen including chronic obstructive pulmonary disease (COPD) requiring chronic treatment, interstitial lung disease (ILD) requiring immunosuppressive therapy, and asthma requiring chronic steroid (other than inhaled steroid) or biologic therapy. 9. History of moderate to severe atherosclerotic cardiovascular disease as evidenced by prior coronary artery bypass surgery, coronary artery stent placement, myocardial infarction, symptomatic carotid arterial disease, peripheral vascular disease, abdominal aortic aneurysm; or angina within the past 8 weeks prior to Visit 1 (Day 0). 10. History of keloid scarring. 11. History of any lymphoproliferative disorder or other malignancy with the exception of successfully treated or excised basal cell or squamous cell skin cancer or cervical cancer in situ. 12. Other autoimmune diseases likely to require immunosuppression. 13. Any of the following lab results at screening: 1. Hemoglobin \<9.5 g/dL 2. White Blood Cell count \<3.5 x 109/L 3. Absolute Neutrophil count \<1.2 x 109/L 4. Platelet count \<120 x 109/L 5. Absolute Lymphocyte count \<0.75 x 109/L 6. Alanine Aminotransferase (ALT) or Aspartate Aminotransferase (AST) \> 1.5 × the upper limit of normal (ULN) 7. Total bilirubin \> ULN 8. Estimated glomerular filtration rate \[GFR\] \<60mL/min/1.73 m2 9. Triglycerides ≥ 300 mg/dL (fasting not required) 10. Total Cholesterol ≥ 240 mg/dL (fasting not required). 14. Major surgery \< 8 weeks prior to Visit 1 (Day 0). 15. Hospitalized for serious infection \< 4 weeks prior to Visit 1 (Day 0). 16. Chronic infections other than chronic or intermittent uncomplicated urinary tract infections (including but not limited to tuberculosis, chronic pyelonephritis, osteomyelitis). 17. Presumed or documented COVID-19 infection within 30 days prior to Visit 1 (Day 0). 18. Recent (within one month prior to screening) close contact with a person who has active TB infection. 19. History of untreated active or latent TB infection. 20. History of incompletely treated active or latent TB infection unless at least one month of treatment has been completed prior to screening. 21. Positive Interferon-Gamma Release Assay (IGRA) or positive purified protein derivative tuberculin skin test (PPD) (\> 5mm induration) at screening. 22. An indeterminate IGRA at screening unless followed by a subsequent negative IGRA or negative PPD. 23. History of human immunodeficiency virus (HIV). 24. A positive test for HIV antigen/antibody or nucleic acid test (NAT) at screening. 25. History of a hepatitis B infection. 26. A positive test for hepatitis B surface antigen or hepatitis B core antibody at screening. 27. History of a hepatitis C infection. 28. A positive test for hepatitis C antibody (regardless of whether hepatitis C RNA levels are undetectable) at screening. 29. History of recurrent (more than one episode) herpes zoster, one or more episodes of any of the following: herpes zoster ophthalmicus, or disseminated herpes zoster, or disseminated herpes simplex. 30. Current, recent (\< 4 weeks prior to Visit 1 (Day 0)) or chronic use of antibiotic medication, except for suppression of chronic/recurrent urinary tract infection, which is allowed. 31. Simultaneous use of more than one of the following: leflunomide, methotrexate and MMF. 32. Any of the following active medications (oral or parenteral): cyclosporine, voclosporin, cyclophosphamide, tacrolimus, rituximab or other anti-CD20s, or any other investigational or marketed biologic with immunomodulatory properties within a year prior to Visit 1 (Day 0). 33. Any of the following medications (oral or parenteral): azathioprine or belimumab within 3 months prior to Visit 1 (Day 0). 34. Any prior treatment with cell-depleting therapies other than anti-CD20s including but not limited to CAMPATH, anti-CD4, anti-CD5, anti-CD3, anti-CD19 products. 35. Intravenous or intramuscular corticosteroids within 2 weeks prior to Visit 1 (Day 0). 36. Treatment with any investigational agent ≤ 4 weeks or ≤ 5 half-lives of the investigational drug prior to Visit 1 (Day 0), whichever is longer. 37. Treatment with more than one dose of ketoconazole within one week of screening. 38. Any prior treatment with chlorambucil, bone marrow transplantation, or total lymphoid irradiation. 39. Vaccinated or exposed by close contact, e.g., within a household, to a live/attenuated vaccine ≤ 6 weeks prior to Visit 1 (Day 0); or is expected to be vaccinated or to have household exposure to these vaccines during treatment or during the 6 weeks following discontinuation of study medication. 40. Received a non-live vaccine ≤ 2 weeks prior to initiation of study drug, or unwillingness of a participant to delay non-live vaccination until 1 month after completion of study therapy. 41. Pregnant or breastfeeding females. 42. History of alcohol or substance abuse, unless in full remission for greater than 6 months prior to first dose of study drug. 43. Past or current medical or psychiatric conditions or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.