The detection of miRNA (non-coding ribonucleic acid) in the blood in the context of active tuberculosis is an innovative approach to the detection of new disease-specific biomarkers. The primary goal of this analysis is to define, for the first time, an miRNA fingerprint for tuberculosis in sweat. Samples that were collected as part of the Sweatb Study (NCT03667742) project are examined for the occurrence of disease-specific, non-coding miRNAs to define new biomarkers in the sweat. These biomarkers can be detected non-invasively and will help in the detection of patients with active tuberculosis.
Study Type
OBSERVATIONAL
Next Generation Sequencing of sweat and whole blood samples for non-coding miRNAs to define biomarkers that enable to differentiate between patients with active tuberculosis, a differential diagnostic disease and healthy individuals.
Detection of miRNA (non-coding ribonucleic acid) in sweat
Analysis of sweat protein markers in patients with active tuberculosis
Time frame: Sweat samples taken at baseline
Detection of miRNA (non-coding ribonucleic acid) in blood
Analysis of blood protein markers in patients with active tuberculosis
Time frame: Blood samples taken at baseline
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