Recently, Analgesia Nociception Index (ANI) has been evaluated for objectively measuring peri-operative pain and to guide intra-operative opioid administration during various surgeries. Propofol injection pain (PIP) is a common problem and can be very distressing to the patient.
This study aimed to the association of preanesthetic ANI scores and PIP in patients who scheduled for general anesthesia. Before propofol administration in remifentanil group, preanesthetic ANI values (instant and mean) were checked after remifentanil to a target Ce of 4 ng/ml. Control group received the same volume of saline as remifentanil group. Heart rate and bispectral index were checked as ANI. Point biserial correlation and ROC curve were analyzed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
TRIPLE
Enrollment
124
V1 and V5 electrocardiographic positions as per the manufacturer's recommendations. The ANI was continuously recorded and displayed with a frequency of 1 Hz. ANI scores measured immediately before propofol administration, half-dose administration (1mg/kg), and full-dose administration (2mg/kg)of propofol.
WonwangUH
Iksan, Jeollabuk-do, South Korea
The correlation of Analgesia/nociception Index (ANI) and Propofol injection pain (PIP)
The correlation of preanesthetic ANI scores and incidence of PIP.
Time frame: Immediately before administration of propofol (2mg/kg)
Incidence and severity of PIP
Incidence and severity with numeric rating scales( 0= no pain, 100=worst pain) of propofol injection pain
Time frame: during anesthesia induction ( half-dose (1mg/kg) and full-dose of (2mg/kg) propofol administration)
The correlation of Analgesia/nociception Index (ANI) and Propofol injection pain (PIP)
The correlation of preanesthetic ANI scores and severity of PIP.
Time frame: Immediately before administration of propofol (2mg/kg)
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