Grounding (Earthing) refers to the practice of contacting the Earth or a properly installed grounding mat with the body. Previous studies on grounding have shown positive effects body-wide inflammation, acute and chronic pain, and immune system response. Prior studies on the inflammatory process of mild cognitive impairment due to Alzheimer's disease, Alzheimer's disease, and some other dementias have shown connections between immune system dysregulation, inflammatory markers, and severe disease progression. Finding ways to mitigate or turn off the inflammatory response is key to treating mild cognitive impairment due to Alzheimer's disease. The purpose of this study is to evaluate the effects of sleeping grounded on cognition and personal perceptions in participants with a diagnosis of mild cognitive impairment due to Alzheimer's disease as evidenced by a battery of assessments using Cogstate's Cognitive Brief Battery and a qualitative questionnaire. We hypothesize that assessment scores will improve with grounding and that perceptions will positively correlate with an increase in scores. Modulation of risk factors like glucocorticoid resistance, SCI, and immune system dysfunction through grounding may lead to an accessible, natural technique for neurodegenerative disease prevention or treatment.
Grounding (Earthing) refers to the practice of contacting the Earth or a properly installed grounding mat with the body. Previous studies on grounding have shown positive effects on diurnal cortisol regulation, systemic chronic inflammation (SCI), immune system response, acute and chronic pain, mood, vagal tone, blood viscosity, blood flow, recovery from muscle strain and damage, and prevention or mitigation of chronic inflammatory and autoimmune diseases. Prior studies on the inflammatory process of mild cognitive impairment due to Alzheimer's disease, Alzheimer's disease, and some other dementias have shown connections between immune system dysregulation, inflammatory markers, and severe disease progression. The purpose of this study is to evaluate the effects of sleeping grounded on cognition and personal perceptions in participants with a diagnosis of mild cognitive impairment due to Alzheimer's disease (MCI/AD) as evidenced by a battery of tests using the Cogstate platform's Cognitive Brief Battery (CBB) and a qualitative questionnaire to detect any correlations to the participant's perceptions of sleep quality, mood, pain, and overall well-being. This study will both fulfill the requirement for a Bachelor of Science in Psychology and lay the foundation for further research into grounding and neurodegenerative diseases. My senior research project methodology is a mixed methods research design with a triangulation convergence, since I'll be concurrently collecting, analyzing, and evaluating the results of the quantitative and qualitative measurements before comparing, integrating, and interpreting the outcomes. I have three hypotheses. First, I hypothesize that sleeping while grounded will result in improved scores on the Cogstate battery of tests given at baseline and weekly for three weeks. Second, I hypothesize that sleeping while grounded will result in positive perceptions regarding sleep quality, mood, pain, and overall well-being. Finally, I hypothesize that improved Cogstate scores will positively correlate with perceptions of sleep quality, mood, and overall well-being and negatively correlate with pain. The independent variable is the intervention (grounded sleeping mat), and the dependent variables are the three measurements of cognition (memory, working memory, and processing speed) and the qualitative questionnaire to evaluate how the participants feel about their sleep quality, mood, pain, and overall well-being. The target population for this study will be adults aged 55 and up (N=8) with a current diagnosis of MCI/AD who meet the inclusion and exclusion criteria. I will employ a mixed methods research design that includes statistical analysis of empirical data and a qualitative questionnaire. I will use a triangulation convergence, since I'll be concurrently collecting, analyzing, and evaluating the results of the quantitative and qualitative measurements before comparing, integrating, and interpreting the outcomes. First, I will look at the percentage of change in each testing area from week to week and calculate the statistical significance (p \< .01) of any changes. Second, I will calculate the mean of all the test scores per day (baseline and weekly X 3) to obtain a general cognition score which I will also use to calculate statistical significance (p \< .01) of changes over time. Third, I will perform a simple linear regression analysis to determine if a correlation exists between the intervention and the cognition scores after baseline. Finally, I will perform an analysis of the qualitative questionnaire using in vivo coding to determine if any correlations exist between the cognition scores and personal perceptions. For this study, I will interpret the results based on changes in test scores over time, changes in general cognition scores over time, and positive/negative correlations of the personal perceptions and cognition scores. Each participant will receive an Earthing Elite™ sleep mat kit which they get to keep. The sleeping mat will be installed wherever the participant sleeps (bed or recliner), and I will ensure that the mat is properly attached to the grounding plug and confirm grounding using a multimeter with two terminal leads, a cord with alligator clips on both ends, an Earthing coil cord, and an outlet checker. This procedure will show body voltage prior to grounding and while grounding to confirm that the setup is working and that body voltage has been neutralized. I will return for repeat assessments after one week, two weeks, and three weeks at which time I will verify that the system is still working properly. All computerized testing will consist of the following assessments on the Cogstate platform: 1) Detection test (psychomotor function); 2) Identification test (attention); 3) One Card Learning test (visual learning); and 4) One Back test (working memory). The personal perceptions qualitative questionnaire will consist of several open-ended and scaled questions designed to assess how the participants perceive various subjective areas such as sleep quality, pain, mood, and overall well-being. Each participant will complete the questionnaire first before completing the computerized cognition assessments. Modulation of risk factors like glucocorticoid resistance, SCI, and immune system dysfunction through grounding may lead to an accessible, natural technique for neurodegenerative disease prevention or treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
8
Participants will sleep on an Earthing Elite sleep mat produced and sold by Earthing.com
Baseline Psychomotor Function Score
In this simple reaction time Detection test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up (revealing a Joker card - this same card is used throughout the test). The subject is asked to press the "YES" button as soon as the card turns face-up. Assessed at baseline then weekly for three weeks.
Time frame: Baseline
Week 1 Psychomotor Function Score
In this simple reaction time Detection test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up (revealing a Joker card - this same card is used throughout the test). The subject is asked to press the "YES" button as soon as the card turns face-up. Assessed at baseline then weekly for three weeks.
Time frame: Week 1
Week 2 Psychomotor Function Score
In this simple reaction time Detection test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up (revealing a Joker card - this same card is used throughout the test). The subject is asked to press the "YES" button as soon as the card turns face-up. Assessed at baseline then weekly for three weeks.
Time frame: Week 2
Week 3 Psychomotor Function Score
In this simple reaction time Detection test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up (revealing a Joker card - this same card is used throughout the test). The subject is asked to press the "YES" button as soon as the card turns face-up. Assessed at baseline then weekly for three weeks.
Time frame: Week 3
Change from Baseline to Week 3 Psychomotor Function Score
In this simple reaction time Detection test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up (revealing a Joker card - this same card is used throughout the test). The subject is asked to press the "YES" button as soon as the card turns face-up. Assessed at baseline then weekly for three weeks. Change = (Week 3 Psychomotor Function Score - Baseline Psychomotor Function Score).
Time frame: Change from baseline to week 3
Baseline Attention Score
In this choice reaction time Identification test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. Either a red Joker card or black Joker card will be revealed. As soon as the card turns face-up, the subject decides whether the card displayed is red. If the card is red, the subject should press the "YES" button, if it is not red, they should press "NO". Assessed at baseline then weekly for three weeks.
Time frame: Baseline
Week 1 Attention Score
In this choice reaction time Identification test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. Either a red Joker card or black Joker card will be revealed. As soon as the card turns face-up, the subject decides whether the card displayed is red. If the card is red, the subject should press the "YES" button, if it is not red, they should press "NO". Assessed at baseline then weekly for three weeks.
Time frame: Week 1
Week 2 Attention Score
In this choice reaction time Identification test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. Either a red Joker card or black Joker card will be revealed. As soon as the card turns face-up, the subject decides whether the card displayed is red. If the card is red, the subject should press the "YES" button, if it is not red, they should press "NO". Assessed at baseline then weekly for three weeks.
Time frame: Week 2
Week 3 Attention Score
In this choice reaction time Identification test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. Either a red Joker card or black Joker card will be revealed. As soon as the card turns face-up, the subject decides whether the card displayed is red. If the card is red, the subject should press the "YES" button, if it is not red, they should press "NO". Assessed at baseline then weekly for three weeks.
Time frame: Week 3
Change from Baseline to Week 3 Attention Score
In this choice reaction time Identification test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. Either a red Joker card or black Joker card will be revealed. As soon as the card turns face-up, the subject decides whether the card displayed is red. If the card is red, the subject should press the "YES" button, if it is not red, they should press "NO". Assessed at baseline then weekly for three weeks. Change = (Week 3 Attention Score - Baseline Attention Score).
Time frame: Baseline to week 4
Baseline Visual Learning Score
In this pattern separation One Card Learning test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card has been seen before in the test. The subject should press the "YES" button if they have seen the card before in the test, or "NO" if they have not. Assessed at baseline then weekly for three weeks.
Time frame: Baseline
Week 1 Visual Learning Score
In this pattern separation One Card Learning test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card has been seen before in the test. The subject should press the "YES" button if they have seen the card before in the test, or "NO" if they have not. Assessed at baseline then weekly for three weeks.
Time frame: Week 1
Week 2 Visual Learning Score
In this pattern separation One Card Learning test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card has been seen before in the test. The subject should press the "YES" button if they have seen the card before in the test, or "NO" if they have not. Assessed at baseline then weekly for three weeks.
Time frame: Week 2
Week 3 Visual Learning Score
In this pattern separation One Card Learning test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card has been seen before in the test. The subject should press the "YES" button if they have seen the card before in the test, or "NO" if they have not. Assessed at baseline then weekly for three weeks.
Time frame: Week 3
Change from Baseline to Week 3 Visual Learning Score
In this pattern separation One Card Learning test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card has been seen before in the test. The subject should press the "YES" button if they have seen the card before in the test, or "NO" if they have not. Assessed at baseline then weekly for three weeks. Change = (Week 3 Visual Learning Score - Baseline Visual Learning Score).
Time frame: Baseline to Week 3
Baseline Working Memory Score
In this N-back One Back test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card is the same as the previous card. The subject should press the "YES" button if the current card is the same as the one presented immediately before it, or "NO" if it is not the same. Assessed at baseline and weekly for three weeks.
Time frame: Baseline
Week 1 Working Memory Score
In this N-back One Back test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card is the same as the previous card. The subject should press the "YES" button if the current card is the same as the one presented immediately before it, or "NO" if it is not the same. Assessed at baseline and weekly for three weeks.
Time frame: Week 1
Week 2 Working Memory Score
In this N-back One Back test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card is the same as the previous card. The subject should press the "YES" button if the current card is the same as the one presented immediately before it, or "NO" if it is not the same. Assessed at baseline and weekly for three weeks.
Time frame: Week 2
Week 3 Working Memory Score
In this N-back One Back test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card is the same as the previous card. The subject should press the "YES" button if the current card is the same as the one presented immediately before it, or "NO" if it is not the same. Assessed at baseline and weekly for three weeks.
Time frame: Week 3
Change from Baseline to Week 3 Working Memory Score
In this N-back One Back test, a playing card is presented face-down in the center of the screen. After a random interval, the card will turn over so that is it face-up. A regular playing card from a French deck is revealed. As soon as the card turns face-up, the subject must decide whether the current card is the same as the previous card. The subject should press the "YES" button if the current card is the same as the one presented immediately before it, or "NO" if it is not the same. Assessed at baseline and weekly for three weeks. Change = (Week 3 Working Memory Score - Baseline Working Memory Score).
Time frame: Baseline and Week 3
Baseline Sleep Quality Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about sleep quality while the second question about sleep quality is scaled. Possible scores range from 0 (worst sleep quality) to 10 (best sleep quality).
Time frame: Baseline
Week 1 Sleep Quality Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about sleep quality while the second question about sleep quality is scaled. Possible scores range from 0 (worst sleep quality) to 10 (best sleep quality).
Time frame: Week 1
Week 2 Sleep Quality Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about sleep quality while the second question about sleep quality is scaled. Possible scores range from 0 (worst sleep quality) to 10 (best sleep quality).
Time frame: Week 2
Week 3 Sleep Quality Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about sleep quality while the second question about sleep quality is scaled. Possible scores range from 0 (worst sleep quality) to 10 (best sleep quality).
Time frame: Week 3
Change from Baseline to Week 3 Sleep Quality Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about sleep quality while the second question about sleep quality is scaled. Possible scores range from 0 (worst sleep quality) to 10 (best sleep quality). Change = (Week 3 Sleep Quality Score - Baseline Sleep Quality Score).
Time frame: Week 3
Baseline Pain Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about pain while the second question about pain is scaled. Possible scores range from 0 (no pain) to 10 (worst pain).
Time frame: Baseline
Week 1 Pain Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about pain while the second question about pain is scaled. Possible scores range from 0 (no pain) to 10 (worst pain).
Time frame: Week 1
Week 2 Pain Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about pain while the second question about pain is scaled. Possible scores range from 0 (no pain) to 10 (worst pain).
Time frame: Week 2
Week 3 Pain Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about pain while the second question about pain is scaled. Possible scores range from 0 (no pain) to 10 (worst pain).
Time frame: Week 3
Change from Baseline to Week 3 Pain Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about pain while the second question about pain is scaled. Possible scores range from 0 (no pain) to 10 (worst pain).
Time frame: Baseline to Week 3
Baseline Mood Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about mood while the second question about mood is scaled. Possible scores range from 0 (worst mood) to 10 (best mood).
Time frame: Baseline
Week 1 Mood Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about mood while the second question about mood is scaled. Possible scores range from 0 (worst mood) to 10 (best mood).
Time frame: Week 1
Week 2 Mood Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about mood while the second question about mood is scaled. Possible scores range from 0 (worst mood) to 10 (best mood).
Time frame: Week 2
Week 3 Mood Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about mood while the second question about mood is scaled. Possible scores range from 0 (worst mood) to 10 (best mood).
Time frame: Week 3
Change from Baseline to Week 3 Mood Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about mood while the second question about mood is scaled. Possible scores range from 0 (worst mood) to 10 (best mood).
Time frame: Baseline to Week 3
Baseline Overall Well-Being Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about overall well-being while the second question about overall well-being is scaled. Possible scores range from 0 (worst overall well-being) to 10 (best overall well-being).
Time frame: Baseline
Week 1 Overall Well-Being Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about overall well-being while the second question about overall well-being is scaled. Possible scores range from 0 (worst overall well-being) to 10 (best overall well-being).
Time frame: Week 1
Week 2 Overall Well-Being Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about overall well-being while the second question about overall well-being is scaled. Possible scores range from 0 (worst overall well-being) to 10 (best overall well-being).
Time frame: Week 2
Week 3 Overall Well-Being Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about overall well-being while the second question about overall well-being is scaled. Possible scores range from 0 (worst overall well-being) to 10 (best overall well-being).
Time frame: Week 3
Change from Baseline to Week 3 Overall Well-Being Score
The Personal Perceptions Questionnaire is a self-designed instrument assessing a participant's perception about their average sleep quality, mood, pain, and well-being over the past 7 days. One question is open-ended and uses in vivo coding to create a score about overall well-being while the second question about overall well-being is scaled. Possible scores range from 0 (worst overall well-being) to 10 (best overall well-being).
Time frame: Baseline to Week 3
Correlation of Change in Psychomotor Function Score and Sleep Quality Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Psychomotor Function Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Sleep Quality Score.
Time frame: Baseline to Week 3
Correlation of Change in Psychomotor Function Score and Pain Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Psychomotor Function Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Pain Score.
Time frame: Baseline to Week 3
Correlation of Change in Psychomotor Function Score and Mood Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Psychomotor Function Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Mood Score.
Time frame: Baseline to Week 3
Correlation of Change in Psychomotor Function Score and Overall Well-Being Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Psychomotor Function Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Overall Well-Being Score.
Time frame: Baseline to Week 3
Correlation of Change in Attention Score and Sleep Quality Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Attention Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Sleep Quality Score.
Time frame: Baseline to Week 3
Correlation of Change in Attention Score and Pain Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Attention Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Pain Score.
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Time frame: Baseline to Week 3
Correlation of Change in Attention Score and Mood Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Attention Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Mood Score.
Time frame: Baseline to Week 3
Correlation of Change in Attention Score and Overall Well-Being Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Attention Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Overall Well-Being Score.
Time frame: Baseline to Week 3
Correlation of Change in Visual Learning Score and Sleep Quality Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Visual Learning Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Sleep Quality Score.
Time frame: Baseline to Week 3
Correlation of Change in Visual Learning Score and Pain Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Visual Learning Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Pain Score.
Time frame: Baseline to Week 3
Correlation of Change in Visual Learning Score and Mood Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Visual Learning Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Mood Score.
Time frame: Baseline to Week 3
Correlation of Change in Visual Learning Score and Overall Well-Being Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Visual Learning Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Overall Well-Being Score.
Time frame: Baseline to Week 3
Correlation of Change in Working Memory Score and Sleep Quality Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Working Memory Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Sleep Quality Score.
Time frame: Baseline to Week 3
Correlation of Change in Working Memory Score and Pain Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Working Memory Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Pain Score.
Time frame: Baseline to Week 3
Correlation of Change in Working Memory Score and Mood Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Working Memory Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Mood Score.
Time frame: Baseline to Week 3
Correlation of Change in Working Memory Score and Overall Well-Being Score from Baseline to Week 3
Using simple regression to assess Baseline to Week 3 change in Working Memory Score and whether that change positively or negatively correlates to the Change from Baseline to Week 3 Overall Well-Being Score.
Time frame: Baseline to Week 3