This trial aims to validate a novel clinical care strategy based on a electronic clinical decision support algorithm (CDSA) combined with point of care rapid diagnostic tests by evaluating its impact on antibiotic prescription and clinical outcome of children and adolescent presenting at primary healthcare facilities with non-severe acute illness compared to routine practice. The trial also aims to assess the usability of the CDSA strategy. The study will be conducted in primary healthcare facilities across different epidemiological regions of Senegal.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
470
The CDSA strategy is a combination of point of care tests (rapid diagnostic tests targeting malaria, dengue fever and streptococcus group a sore through) and a mHealth tool that provides patient management recommendations, including treatment, based on an algorithm integrating patient clinical signs and symptoms, history and diagnostic test results.
PS Ndiaye-Fatick
Fatick, Senegal
RECRUITINGPS Kedougou-Dalaba
Kédougou, Senegal
RECRUITINGPS Mbour-Toucouleur
Mbour, Senegal
RECRUITINGPS Pont-Tambacounda
Tambacounda, Senegal
RECRUITINGNon-inferiority of the CDSA strategy when compared to routine practice in terms of clinical status assessed at Day 7
This will be measured as point estimates of the percent change of patient with resolved illness at Day 7 in the intervention arm, as compared to the control arm.
Time frame: 4 months
Superiority of the CDSA strategy when compared to routine practice in terms of antibiotic prescription at Day 0
This will be measured as point estimates of the percent change of antibiotic prescription at Day 0 in the intervention arm, as compared to the control arm and to site-specific historical data. This measure aims to assess rational use of antibiotics using the CDSA strategy compared to routine practice.
Time frame: 4 months
Antibiotic prescription rate during 7 days of follow-up in the intervention arm compared to the control arm
This measure will further assess rational antibiotic prescribing using the CDSA strategy compared to routine practice.
Time frame: 4 months
Diagnostic performance of the dengue rapid diagnostic test (RDT)
The performance of the dengue RDT used in health facilities will be assessed against reference standards.
Time frame: 4 months
Identification of risk factors associated with viral and bacterial infections
This measure aims to better characterize viral and bacterial infections in children and adolescents presenting with acute illness in these settings and improve the next version of the algorithm.
Time frame: 4 months
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