Controlled randomized crossover trial in patients with chronic obstructive respiratory disease (COPD), who are treated with Nasal High Flow (NHF) therapy during wakefulness with a small amount of CO2 added to the inhaled air to keep the patients' PaCO2 stable despite the washout effect. Aim of the study is to examine respiratory rate, tidal volume and work of breathing under NHF without the CO2 washout effect.
In this controlled randomized crossover trial, 10 stable patients with chronic obstructive respiratory disease (COPD) are treated with Nasal High Flow (NHF) therapy during wakefulness. NHF treatment will inevitably result in increased upper airway washout and thus in a slight reduction of PaCO2 of approximately 2 mmHg. For compensation, a small amount of CO2 is added to the inhaled air during this experimental situation, which keeps the patients' PaCO2 stable. This will allow to examine the effects of NHF therapy on respiratory rate, tidal volume and work of breathing, that are not attributable to the CO2 washout effect.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
10
Patients with chronic respiratory failure are treated for 1 h with NHF therapy and with individual O2 supplementation during wakefulness.
Evang. Kliniken Essen-Mitte gGmbH
Essen, North Rhine-Westphalia, Germany
Minute Ventilation
Difference in respiratory minute volume under NHF versus NHF/CO2.
Time frame: up to 1 hour
Tidal Volume
Difference in tidal volume (VT) under NHF versus NHF/CO2
Time frame: up to 1 hour
Respiratory Rate
Difference in respiratory rate under NHF versus NHF/CO2.
Time frame: up to 1 hour
Transcutaneous pCO2
Difference in transcutaneous pCO2 under NHF versus NHF/CO2.
Time frame: up to 1 hour
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.